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U.S. population at increased risk of severe illness from COVID-19

American journal of preventive cardiology, 2021-06, Vol.6, p.100156-100156, Article 100156 [Peer Reviewed Journal]

2021 The Authors ;2021 The Authors. ;2021 The Authors 2021 ;ISSN: 2666-6677 ;EISSN: 2666-6677 ;DOI: 10.1016/j.ajpc.2021.100156 ;PMID: 33615285

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  • Title:
    U.S. population at increased risk of severe illness from COVID-19
  • Author: Ajufo, Ezimamaka ; Rao, Shreya ; Navar, Ann Marie ; Pandey, Ambarish ; Ayers, Colby R. ; Khera, Amit
  • Subjects: Short Report
  • Is Part Of: American journal of preventive cardiology, 2021-06, Vol.6, p.100156-100156, Article 100156
  • Description: The U.S. Centers for Disease Control and Prevention (CDC) recognizes that older adults and individuals with certain medical conditions are at increased risk of severe COVID-19 infection. Understanding the proportion of the population at risk of severe infection, including among those with heart disease, could assist current vaccine strategy efforts. Using data from the 2015-2018 National Health and Nutrition Examination Survey (NHANES), we estimated the weighted prevalence of any of eight of eleven increased-risk conditions (including age ≥65) in U.S. adults aged ≥18 (N = 10,581) and extrapolated these results to a population of 233.8 million U.S. adults ≥18, and subgroups from the overall population defined by race/ethnicity, education, income and history of heart disease. An estimated 176.1 million individuals representing 75.4% of U.S. adults had at least one increased-risk condition, 40.3% ≥2 and, 18.5% ≥3 conditions. Approximately 129 million adults aged <65 (69.2%) were also estimated to be at increased-risk. Compared to Whites, similar proportions of Blacks in the overall population (78.0 vs. 75.6%, p>0.05) and Hispanics in the younger population (70.8 vs 68.4%) were estimated to be at increased-risk. Conversely, a greater proportion of individuals with lower education and income levels were estimated to be at increased-risk both in the overall and younger population. In addition, an estimated 6.2 million individuals (14.5%) had heart disease. Among these, virtually all had at least one additional CDC risk factor (97.9%) and most had ≥2 or ≥3 risk factors (83.8% and 58.5%, respectively). As vaccination strategies are being explored, these results demonstrate that >75% of adults in the U.S. would be considered at increased-risk for severe COVID-19 infection by CDC criteria. Risk factor prevalence alone may not adequately capture the totality of risk, particularly among Black and Hispanic racial/ethnic groups and those with heart disease.
  • Publisher: Netherlands: Elsevier B.V
  • Language: English
  • Identifier: ISSN: 2666-6677
    EISSN: 2666-6677
    DOI: 10.1016/j.ajpc.2021.100156
    PMID: 33615285
  • Source: PubMed Central
    DOAJ Directory of Open Access Journals
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