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Molecular subtypes of Adenovirus-associated acute respiratory infection outbreak in children in Northern Vietnam and risk factors of more severe cases

PLoS neglected tropical diseases, 2023-11, Vol.17 (11), p.e0011311-e0011311 [Peer Reviewed Journal]

COPYRIGHT 2023 Public Library of Science ;ISSN: 1935-2735 ;ISSN: 1935-2727 ;EISSN: 1935-2735 ;DOI: 10.1371/journal.pntd.0011311

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Title:
Molecular subtypes of Adenovirus-associated acute respiratory infection outbreak in children in Northern Vietnam and risk factors of more severe cases
Author: Nguyen, Dinh-Dung ; Phung, Lan Tuyet ; Thanh Tran, Huyen Thi ; Ly, Ha Thi Thanh ; Vo, Anh Hang Mai ; Dinh, Nhung Phuong ; Doan, Phuong Mai ; Nguyen, Anh Thi ; Dang, Luc Danh ; Doan, Thia Thi ; Pham, Khuong Thi ; Pham, Huong Lan ; Hoang, Dai Xuan ; Pham, Thao Ngoc ; Tran, Bao Thai ; Tran, Trang Thi Thuc ; Le, Huong Thi Minh ; Pham, An Nhat ; Antoniou, Antony ; Ho, Nhan Thi
Nzelu, Chukwunonso
Subjects: Adenoviruses ; Analysis ; Bacterial pneumonia ; Care and treatment ; Children ; Control ; Diagnosis ; Epidemics ; Health aspects ; Medical research ; Medicine, Experimental ; Molecular dynamics ; Pediatrics ; Pneumonia ; Risk factors ; Vietnam
Is Part Of: PLoS neglected tropical diseases, 2023-11, Vol.17 (11), p.e0011311-e0011311
Description: Background Under the pressure of Human Adenovirus (HAdV)-associated acute respiratory infection (ARI) outbreak in children in Northern Vietnam in the end of 2022, this study was initiated to identify the HAdV subtype(s) and examine the associated clinical features and risk factors of more severe cases. Methods This study evaluated pediatric patients with ARI which had tested positive for HAdV between October and November 2022 using a multiplex real-time PCR panel. Nasopharyngeal aspirates or nasal swab samples were used for sequencing to identify HAdV subtypes. Clinical data were collected retrospectively. Results Among 97 successfully sequenced samples, the predominant subtypes were HAdV-B3 (83%), HAdV-B7 (16%) and HAdV-C2 (1%). Lower respiratory manifestations were found in 25% of the patients of which 5% were diagnosed with severe pneumonia. There was no significant association between HAdV subtype and clinical features except higher white blood cell and neutrophil counts in those detected with HAdV-B3 (p<0.001). Co-detection of HAdV with [greater than or equal to]1 other respiratory viruses was found in 13/24(54%) of those with lower respiratory manifestations and 4/5(80%) of those with severe pneumonia (odds ratio (95% confidence interval) vs. those without = 10.74 (2.83, 48.17) and 19.44 (2.12, 492.73) respectively after adjusting for age, sex, birth delivery method, day of disease). Conclusion HAdV-B3 and HAdV-B7 were predominant in the outbreak. Co-detection of HAdV together with other respiratory viruses was a strong risk factor for lower respiratory tract illnesses and severe pneumonia. The findings advocate the advantages of multi-factor microbial panels for the diagnosis and prognosis of ARI in children.
Publisher: Public Library of Science
Language: English
Identifier: ISSN: 1935-2735
ISSN: 1935-2727
EISSN: 1935-2735
DOI: 10.1371/journal.pntd.0011311
Source: Public Library of Science (PLoS) Journals Open Access
Freely Accessible Journals
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Molecular subtypes of Adenovirus-associated acute respiratory infection outbreak in children in Northern Vietnam and risk factors of more severe cases

COPYRIGHT 2023 Public Library of Science ;ISSN: 1935-2735 ;ISSN: 1935-2727 ;EISSN: 1935-2735 ;DOI: 10.1371/journal.pntd.0011311

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