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Multipleroles of SOCS proteins: Differential expressions of SOCS1 and SOCS3 in atherosclerosis

Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban, 2019-01 (3), p.343

Copyright Xi'an Jiaotong University 2019 ;ISSN: 1671-8259 ;DOI: 10.7652/jdyxb201903002

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  • Title:
    Multipleroles of SOCS proteins: Differential expressions of SOCS1 and SOCS3 in atherosclerosis
  • Author: LIANG, Xiao ; HE, Ming ; Yu-ling, TIAN ; Yu-liang, WU ; Zu-yi, YUAN
  • Subjects: Atherosclerosis ; Cardiovascular disease ; Protein expression ; Rodents
  • Is Part Of: Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban, 2019-01 (3), p.343
  • Description: Objective: To illuminate the changes in expression of suppressor of cytokine signaling (SOCS) and the correlation between SOCS expression and cholesterol levels in atherosclerosis (AS). Methods: A mouse AS model was established in apolipoprotein-deficient (ApoE-/-) mice. The mice were fed either with a chow or high-fat diet. The mRNA and protein expressions of SOCS1 and SOCS3 in plaque and vessels were determined at different time points. Furthermore, SOCS1 and SOCS3 mRNA expressions were detected in the peripheral blood mononuclear cells (PBMCs) obtained from 18 male subjects with no coronary heart disease (non-CHD). Results: The expression of SOCS1 in the?ApoE-/- mice increased first and then decreased and the high-fat diet accelerated the appearance of the peak. The expression of SOCS3 increased with the increase of feeding duration, and this trend was more pronounced in the mice fed with high-fat diet. SOCS1/CD68 and SOCS3/CD68 showed the opposite trend in expression with the increased duration of high-fa
  • Publisher: Xi'an: Xi'an Jiaotong University
  • Language: Chinese
  • Identifier: ISSN: 1671-8259
    DOI: 10.7652/jdyxb201903002
  • Source: ProQuest Central
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