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Correlation between the serum concentration of ACE2/Ang (1-7) and the occurrence of atrial fibrillation in patients with rheumatic valvular heart disease / 血清ACE2/Ang(1～7)与风湿性心脏瓣膜病患者心房颤动发生的相关性分析

Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban, 2016-01 (3), p.408

Copyright Xi'an Jiaotong University 2016 ;ISSN: 1671-8259 ;DOI: 10.7652/jdyxb201603022

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  • Title:
    Correlation between the serum concentration of ACE2/Ang (1-7) and the occurrence of atrial fibrillation in patients with rheumatic valvular heart disease / 血清ACE2/Ang(1～7)与风湿性心脏瓣膜病患者心房颤动发生的相关性分析
  • Author: Yong-rong, JIANG ; LIU Ru-ru ; ZHOU, Xin ; Jun-qiang, PAN ; Wen-qi, HAN ; Jin-e, WU ; Tian-yu, MENG ; Chao-feng, SUN
  • Subjects: Cardiac arrhythmia ; Cardiovascular disease ; Heart
  • Is Part Of: Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban, 2016-01 (3), p.408
  • Description: Objective: To reveal the role of serum ACE2/Ang (1-7) in the occurrence of atrial fibrillation (AF) and find new targets for the prevention and treatment of AF by analyzing the correlation between the serum concentration of ACE2/Ang (1-7) in patients with rheumatic valvular heart disease and the occurrence of AF. Methods: We collected the basic clinical information and peripheral venous blood of patients with rheumatic heart valve disease (totally 46 patients, including 24 with AF and 22 with SR). ELISA method was used to detect the serum concentration of ACE2, Ang (1-7) and AngⅡ in the serum samples. Then the differences and correlation between the two groups were analyzed. Results: In the AF group ① the diameter of the left atrium was significantly greater than that in the SR group [(60.70±3.08 vs. 48.15±2.16)mm, P<0.05]; ② the serum concentration of AngⅡ was significantly higher than that in the SR group [(45.88±2.87 vs. 35.78±1.08)pg/mL, P<0.05], AngⅡ and left atrium diameter were positively correlated (P
  • Publisher: Xi'an: Xi'an Jiaotong University
  • Language: Chinese
  • Identifier: ISSN: 1671-8259
    DOI: 10.7652/jdyxb201603022
  • Source: ProQuest Central
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