Language:

Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies

Cardiovascular diabetology, 2019-04, Vol.18 (1), p.48-48, Article 48 [Peer Reviewed Journal]

2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2019 ;ISSN: 1475-2840 ;EISSN: 1475-2840 ;DOI: 10.1186/s12933-019-0851-z ;PMID: 30987625

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies
Author: Ye, Xiaofeng ; Kong, Wen ; Zafar, Mohammad Ishraq ; Chen, Lu-Lu
Subjects: Atherosclerosis ; Bibliographic data bases ; Biomarkers - blood ; Blood pressure ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cholesterol ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - epidemiology ; Dyslipidemias - blood ; Dyslipidemias - diagnosis ; Dyslipidemias - epidemiology ; Health risk assessment ; Health risks ; Heart ; Heart diseases ; Humans ; Lipids ; Lipoproteins ; Meta-analysis ; Prognosis ; Research design ; Review ; Risk Assessment ; Risk Factors ; Statins ; Studies ; Systematic review ; Triglycerides ; Triglycerides - blood ; Type 2 diabetes mellitus ; Up-Regulation
Is Part Of: Cardiovascular diabetology, 2019-04, Vol.18 (1), p.48-48, Article 48
Description: The importance of triglycerides (TG) level as a risk factor for cardiovascular diseases (CVD) has been extensively investigated in the general population; however, their relationship in patients with type 2 diabetes mellitus (T2DM) is uncertain. We aimed to assess the association of TG with CVD in T2DM individuals. We searched bibliographic databases for studies published until June 2018, reporting on the relationship between TG and CVD in T2DM people. A random-effects model with inverse variance weighting was used to compute pooled estimates of the most fully adjusted risk ratios (RR) and corresponding 95% confidence intervals (CI) according to TG categories, unit TG, and logarithm (log) of TG for CVD. A total of 31 studies were included, involving 132,044 T2DM patients with 10,733 incident cardiovascular events. The pooled RR (95% CI) of CVD for an increase in baseline TG, log TG by 1-mmol/l and categorized in the highest vs. the lowest TG in T2DM were 1.06 (1.02, 1.09), 1.30 (1.18, 1.42) and 1.30 (1.16, 1.46), corresponding to a CVD risk increase of 6%, 30% and 30%, respectively. The pooled RR (95% CI) of CVD for per 1-mmol/L TG increment in eight studies and TG categories in three studies were 1.03 (0.98, 1.08) and 1.39 (0.92, 2.1) in T2DM patients adjusted for other lipids parameter, respectively. In T2DM patients, an elevated triglyceride level cannot serve as an independent marker for an increased risk of cardiovascular events, but still, the higher serum TG levels tend to be associated with increased risks of CVD.
Publisher: England: BioMed Central
Language: English
Identifier: ISSN: 1475-2840
EISSN: 1475-2840
DOI: 10.1186/s12933-019-0851-z
PMID: 30987625
Source: PubMed Central (Open access)
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
Springer OA刊
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies

Searching Remote Databases, Please Wait