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Increased SARS-CoV-2 Testing Capacity with Pooled Saliva Samples

Emerging infectious diseases, 2021-04, Vol.27 (4), p.1184-1187 [Peer Reviewed Journal]

COPYRIGHT 2021 U.S. National Center for Infectious Diseases ;Published 2021. This article is a U.S. Government work and is in the public domain in the USA. ;ISSN: 1080-6040 ;EISSN: 1080-6059 ;DOI: 10.3201/eid2704.204200 ;PMID: 33755009

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Title:
Increased SARS-CoV-2 Testing Capacity with Pooled Saliva Samples
Author: Watkins, Anne E ; Fenichel, Eli P ; Weinberger, Daniel M ; Vogels, Chantal B F ; Brackney, Doug E ; Casanovas-Massana, Arnau ; Campbell, Melissa ; Fournier, John ; Bermejo, Santos ; Datta, Rupak ; Dela Cruz, Charles S ; Farhadian, Shelli F ; Iwasaki, Akiko ; Ko, Albert I ; Grubaugh, Nathan D ; Wyllie, Anne L
Subjects: 2019 novel coronavirus disease ; Capacity Building - methods ; coronavirus disease ; Coronaviruses ; Cost control ; COVID-19 ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; COVID-19 Nucleic Acid Testing - methods ; Disease transmission ; Dispatch ; Genetic aspects ; Health Care Rationing ; Humans ; Increased SARS-Cov-2 Testing Capacity with Pooled Saliva Samples ; Laboratories ; Limit of Detection ; Medical diagnosis ; Population ; Resource Allocation - methods ; Saliva ; Saliva - virology ; Salivary glands ; SARS-CoV-2 ; SARS-CoV-2 - isolation & purification ; secretions ; Sensitivity and Specificity ; Severe acute respiratory syndrome coronavirus 2 ; Specimen Handling - methods ; Testing ; United States ; viruses
Is Part Of: Emerging infectious diseases, 2021-04, Vol.27 (4), p.1184-1187
Description: We analyzed feasibility of pooling saliva samples for severe acute respiratory syndrome coronavirus 2 testing and found that sensitivity decreased according to pool size: 5 samples/pool, 7.4% reduction; 10 samples/pool, 11.1%; and 20 samples/pool, 14.8%. When virus prevalence is >2.6%, pools of 5 require fewer tests; when <0.6%, pools of 20 support screening strategies.
Publisher: United States: U.S. National Center for Infectious Diseases
Language: English
Identifier: ISSN: 1080-6040
EISSN: 1080-6059
DOI: 10.3201/eid2704.204200
PMID: 33755009
Source: Centers for Disease Control and Prevention
US Government Documents
Geneva Foundation Free Medical Journals at publisher websites
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PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Increased SARS-CoV-2 Testing Capacity with Pooled Saliva Samples

COPYRIGHT 2021 U.S. National Center for Infectious Diseases ;Published 2021. This article is a U.S. Government work and is in the public domain in the USA. ;ISSN: 1080-6040 ;EISSN: 1080-6059 ;DOI: 10.3201/eid2704.204200 ;PMID: 33755009

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