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Autotomy in rats following peripheral nerve transection is attenuated by preceding formalin injections into the same limb

Neuroscience letters, 1998-02, Vol.243 (1), p.125-128 [Peer Reviewed Journal]

1998 Elsevier Science Ireland Ltd ;1998 INIST-CNRS ;ISSN: 0304-3940 ;EISSN: 1872-7972 ;DOI: 10.1016/S0304-3940(98)00107-4 ;PMID: 9535129 ;CODEN: NELED5

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Title:
Autotomy in rats following peripheral nerve transection is attenuated by preceding formalin injections into the same limb
Author: Abad, Faustino ; Feria, Manuel ; Sánchez, Alberto ; González Mora, José L
Subjects: Animals ; Behavior, Animal - physiology ; Biological and medical sciences ; Denervation ; Denervation pain ; Edema - chemically induced ; Formaldehyde ; Formalin ; Fundamental and applied biological sciences. Psychology ; Hot Temperature ; Hyperalgesia - physiopathology ; Inflammation ; Male ; Nociceptive thresholds ; Nociceptors - physiology ; Pain Threshold - physiology ; Phantom Limb - physiopathology ; Physical Stimulation ; Rat ; Rats ; Rats, Sprague-Dawley ; Sciatic Nerve - surgery ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Vertebrates: nervous system and sense organs
Is Part Of: Neuroscience letters, 1998-02, Vol.243 (1), p.125-128
Description: The influence of an evolving painful inflammatory lesion on the development of autotomy, a behavioural model of denervation pain, was studied in rats suffering sciatic and saphenous nerves transection 30 or 60 min, and 1, 3, 7 or 14 days after being injected with formalin (50 μl, 5%, s.c). Hindpaws pressure and heat nociceptive thresholds and volume of the injected paw were assessed, in non-operated rats, at the above time-points. The main effects on autotomy were: (1) a significant attenuation when formalin injection preceded the neurectomies by 1 day or more, a period characterized by hypalgesia of the injected paw to both mechanical (during the first week) and thermal (spanning up to the third day after formalin) stimuli and inflammation (lasting for 14 days); (2) a significantly earlier onset when formalin was injected 30 min before neurectomies. Possible mechanisms linking nociceptive responsiveness and inflammation to the development of autotomy are discussed.
Publisher: Shannon: Elsevier Ireland Ltd
Language: English
Identifier: ISSN: 0304-3940
EISSN: 1872-7972
DOI: 10.1016/S0304-3940(98)00107-4
PMID: 9535129
CODEN: NELED5
Source: MEDLINE
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Autotomy in rats following peripheral nerve transection is attenuated by preceding formalin injections into the same limb

1998 Elsevier Science Ireland Ltd ;1998 INIST-CNRS ;ISSN: 0304-3940 ;EISSN: 1872-7972 ;DOI: 10.1016/S0304-3940(98)00107-4 ;PMID: 9535129 ;CODEN: NELED5

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