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Acute Laryngeal Dyspnea as the First Presentation of Mantle Cell Lymphoma: A Case Report and Review of the Literature

Case reports in hematology, 2020-09, Vol.2020, p.8818270-4 [Peer Reviewed Journal]

Copyright © 2020 Mounir Ababou et al. ;Copyright © 2020 Mounir Ababou et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 ;Copyright © 2020 Mounir Ababou et al. 2020 ;ISSN: 2090-6560 ;EISSN: 2090-6579 ;DOI: 10.1155/2020/8818270 ;PMID: 32963850

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  • Title:
    Acute Laryngeal Dyspnea as the First Presentation of Mantle Cell Lymphoma: A Case Report and Review of the Literature
  • Author: Ababou, Mounir ; El Maaroufi, Hicham ; Hammani, Adnane ; Jennane, Selim ; Mahtat, El Mehdi ; Mikdame, Mohammed ; Doghmi, Kamal
  • Konstantopoulos, Kostas ; Kostas Konstantopoulos
  • Subjects: Airway management ; Biopsy ; Bone marrow ; Case Report ; Dyspnea ; Edema ; Larynx ; Lymphoma ; Stem cells ; Tracheotomy ; Tumors
  • Is Part Of: Case reports in hematology, 2020-09, Vol.2020, p.8818270-4
  • Description: Introduction. Acute laryngeal dyspnea is a life-threatening emergency, and the causes in adults are most often laryngeal tumors or inflammatory edema. Lymphoma of the larynx and especially the mantle cell type is extremely rare. Case Presentation. We report a case of a 43-year-old woman with no particular pathological history. She presented with progressive dyspnea which has evolved towards an inspiratory bradypnea that worsened until she ultimately required an emergency tracheotomy. Biopsies revealed mantle cell lymphoma. The patient has been staged IVB MIPI 6, and she was treated by immunochemotherapy followed by ASCT. The therapeutic evaluation shows a complete remission, 18 months after, and the patient was always disease free. Conclusion. The laryngeal localization of the mantle cell lymphoma is extremely rare; it may present catastrophically with acute airway obstruction. The diagnosis is mostly histological, hence the interest of deep biopsy. Given its rarity, the therapeutic strategy must be discussed case by case in a multidisciplinary consultation meeting.
  • Publisher: United States: Hindawi
  • Language: English
  • Identifier: ISSN: 2090-6560
    EISSN: 2090-6579
    DOI: 10.1155/2020/8818270
    PMID: 32963850
  • Source: GFMER Free Medical Journals
    PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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