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Studies on phytochemical, antioxidant, anti-inflammatory, hypoglycaemic and antiproliferative activities of Echinacea purpurea and Echinacea angustifolia extracts

Pharmaceutical biology, 2017-01, Vol.55 (1), p.649-656 [Peer Reviewed Journal]

2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2016 ;2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2016 The Author(s). ;ISSN: 1388-0209 ;EISSN: 1744-5116 ;DOI: 10.1080/13880209.2016.1265989 ;PMID: 27951745

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Title:
Studies on phytochemical, antioxidant, anti-inflammatory, hypoglycaemic and antiproliferative activities of Echinacea purpurea and Echinacea angustifolia extracts
Author: Aarland, Rayn Clarenc ; Bañuelos-Hernández, Angel Ernesto ; Fragoso-Serrano, Mabel ; Sierra-Palacios, Edgar del Carmen ; Díaz de León-Sánchez, Fernando ; Pérez-Flores, Laura Josefina ; Rivera-Cabrera, Fernando ; Mendoza-Espinoza, José Alberto
Subjects: Alloxan ; Aluminum chloride ; Animals ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Antioxidants ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Benzothiazoles - chemistry ; Biological activity ; Biomarkers - blood ; Biphenyl Compounds - chemistry ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Caffeic acid ; Carrageenan ; Cell Proliferation - drug effects ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - drug therapy ; Dry matter ; Echinacea ; Echinacea - chemistry ; Echinacea - classification ; Echinacea angustifolia ; Echinacea purpurea ; Edema ; Edema - chemically induced ; Edema - prevention & control ; fingerprints ; Flavonoids ; Flowers ; Glibenclamide ; HeLa Cells ; Herbal ; Humans ; Hypoglycemic Agents - isolation & purification ; Hypoglycemic Agents - pharmacology ; Indomethacin ; Inflammation ; Male ; MCF-7 Cells ; Neoplasms - drug therapy ; Neoplasms - pathology ; Phenols ; Phytochemicals ; Phytochemicals - isolation & purification ; Phytochemicals - pharmacology ; Phytotherapy ; Picrates - chemistry ; Plant extracts ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plants, Medicinal ; Rats, Wistar ; Rodents ; Roots ; Seeds ; Standardization ; Sulfonic Acids - chemistry ; Time Factors
Is Part Of: Pharmaceutical biology, 2017-01, Vol.55 (1), p.649-656
Description: Context: Echinacea (Asteraceae) is used because of its pharmacological properties. However, there are few studies that integrate phytochemical analyses with pharmacological effects. Objective: Evaluate the chemical profile and biological activity of hydroalcoholic Echinacea extracts. Materials and methods: Density, dry matter, phenols (Folin-Ciocalteu method), flavonoids (AlCl 3 method), alkylamides (GC-MS analysis), antioxidant capacity (DPPH and ABTS methods), antiproliferative effect (SRB assay), anti-inflammatory effect (paw oedema assay, 11 days/Wistar rats; 0.4 mL/kg) and hypoglycaemic effect (33 days/Wistar rats; 0.4 mL/kg) were determined in three Echinacea extracts which were labelled as A, B and C (A, roots of Echinacea purpurea L. Moench; B, roots, leaves, flowers and seeds of Echinacea purpurea; C, aerial parts and roots of Echinacea purpurea and roots of Echinacea angustifolia DC). Results: Extract C showed higher density (0.97 g/mL), dry matter (0.23 g/mL), phenols (137.5 ± 2.3 mEAG/mL), flavonoids (0.62 ± 0.02 mEQ/mL), and caffeic acid (0.048 mg/L) compared to A and B. A, B presented 11 alkylamides, whereas C presented those 11 and three more. B decreased the oedema (40%) on day 2 similar to indomethacin. A and C showed hypoglycaemic activity similar to glibenclamide. Antiproliferative effect was only detected for C (IC 50 270 μg/mL; 8171 μg/mL; 9338 μg/mL in HeLa, MCF-7, HCT-15, respectively). Discussion and conclusion: The difference in the chemical and pharmacological properties among extracts highlights the need to consider strategies and policies for standardization of commercial herbal extracts in order to guarantee the safety and identity of this type of products.
Publisher: England: Taylor & Francis
Language: English
Identifier: ISSN: 1388-0209
EISSN: 1744-5116
DOI: 10.1080/13880209.2016.1265989
PMID: 27951745
Source: Taylor & Francis Open Access
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Studies on phytochemical, antioxidant, anti-inflammatory, hypoglycaemic and antiproliferative activities of Echinacea purpurea and Echinacea angustifolia extracts

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