Language:

Disorganization of the Retinal Inner Layers as a Predictor of Visual Acuity in Eyes With Macular Edema Secondary to Vein Occlusion

American journal of ophthalmology, 2017-10, Vol.182, p.160-167 [Peer Reviewed Journal]

2017 Elsevier Inc. ;Copyright © 2017 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Oct 1, 2017 ;ISSN: 0002-9394 ;EISSN: 1879-1891 ;DOI: 10.1016/j.ajo.2017.08.005 ;PMID: 28837790

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Disorganization of the Retinal Inner Layers as a Predictor of Visual Acuity in Eyes With Macular Edema Secondary to Vein Occlusion
Author: Mimouni, Michael ; Segev, Or ; Dori, Dalia ; Geffen, Noa ; Flores, Victor ; Segal, Ori
Subjects: Aged ; Angiogenesis Inhibitors - therapeutic use ; Bevacizumab - therapeutic use ; Biomarkers ; Cohort Studies ; Diabetes ; Diabetic retinopathy ; Edema ; Female ; Fluorescein Angiography ; Humans ; Intravitreal Injections ; Macular degeneration ; Macular Edema - drug therapy ; Macular Edema - etiology ; Macular Edema - physiopathology ; Male ; Medical imaging ; Multivariate analysis ; Ophthalmology ; Retinal Ganglion Cells - pathology ; Retinal Vein Occlusion - complications ; Retinal Vein Occlusion - drug therapy ; Retinal Vein Occlusion - physiopathology ; Retrospective Studies ; Systematic review ; Tomography ; Tomography, Optical Coherence ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - antagonists & inhibitors ; Veins & arteries ; Visual Acuity - physiology
Is Part Of: American journal of ophthalmology, 2017-10, Vol.182, p.160-167
Description: To determine whether spectral-domain optical coherence tomography (SD-OCT) disorganization of the retinal inner layers (DRIL) is predictive of best-corrected visual acuity (BCVA) in retinal vein occlusion macular edema (RVO-ME). Retrospective cohort study. Setting: Two tertiary centers. Patients: Treatment-naïve RVO-ME receiving monthly intravitreal bevacizumab. Observation Procedures: Spectral-domain optical coherence tomography (SD-OCT) images from baseline, 4-month, and 8-month visits. The DRIL extent and additional parameters were evaluated in the 1-mm-wide foveal centered area. Main Outcome Measures: BCVA at each visit. A total of 136 eyes were included in this study. Greater DRIL extent at baseline correlated with worse baseline BCVA (point estimate, 0.04; 95% CI, 0.01–0.07 per 100 μm, P = .003). In multivariate analysis extent of DRIL (P = .03) and ellipsoid zone disruption (P < .001) correlated with baseline BCVA. Four-month DRIL reduction was associated with 8-month BCVA improvement (point estimate, 0.02; 95% CI, 0.01–0.04, P = .01), with only DRIL remaining significant in multivariate analysis (P = .02). Baseline DRIL predicted 8-month improvement in BCVA (point estimate, 0.03; 95% CI, 0.01–0.05, P = .04), with only DRIL remaining significant in multivariate analysis (P = .006). Eight-month DRIL change was associated with 8-month BCVA change (point estimate, 0.03, 95% CI 0.01–0.05, P = .001), with only DRIL remaining significant in multivariate analysis (P = .002). The change of the DRIL extent following the first 3 monthly injections identifies eyes with a high likelihood of subsequent BCVA improvement or decline. Therefore, the extent of DRIL before and after treatment is an additional SD-OCT parameter that may serve as a biomarker for patients with RVO-ME.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0002-9394
EISSN: 1879-1891
DOI: 10.1016/j.ajo.2017.08.005
PMID: 28837790
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Disorganization of the Retinal Inner Layers as a Predictor of Visual Acuity in Eyes With Macular Edema Secondary to Vein Occlusion

2017 Elsevier Inc. ;Copyright © 2017 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Oct 1, 2017 ;ISSN: 0002-9394 ;EISSN: 1879-1891 ;DOI: 10.1016/j.ajo.2017.08.005 ;PMID: 28837790

Searching Remote Databases, Please Wait