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Regulatory phases of early liver development: paradigms of organogenesis

Nature reviews. Genetics, 2002-07, Vol.3 (7), p.499-512 [Peer Reviewed Journal]

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Title:
Regulatory phases of early liver development: paradigms of organogenesis
Author: Zaret, Kenneth S
Subjects: Animals ; Body Patterning ; Ectoderm - physiology ; Embryonic and Fetal Development - physiology ; Endoderm - physiology ; Gene Expression Regulation, Developmental ; Humans ; Liver - embryology
Is Part Of: Nature reviews. Genetics, 2002-07, Vol.3 (7), p.499-512
Description: Genetic analysis, embryonic tissue explantation and in vivo chromatin studies have together identified the distinct regulatory steps that are necessary for the development of endoderm into a bud of liver tissue and, subsequently, into an organ. In this review, I discuss the acquisition of competence to express liver-specific genes by the endoderm, the control of early hepatic growth, the coordination of hepatic and vascular development and the cell differentiation that is necessary to generate a functioning liver. The regulatory mechanisms that underlie these phases are common to the development of many organ systems and might be recapitulated or disrupted during stem-cell differentiation and adult tissue pathogenesis.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-0056
EISSN: 1471-0064
DOI: 10.1038/nrg837
PMID: 12094228
Source: MEDLINE
ProQuest Central

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