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Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review

Oxidative medicine and cellular longevity, 2016-01, Vol.2016, p.8598253-19 [Peer Reviewed Journal]

Copyright © 2016 Konstantina P. Poulianiti et al. ;Copyright © 2016 Konstantina P. Poulianiti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ;Copyright © 2016 Konstantina P. Poulianiti et al. 2016 ;ISSN: 1942-0900 ;EISSN: 1942-0994 ;DOI: 10.1155/2016/8598253 ;PMID: 27563376

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Title:
Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review
Author: Poulianiti, Konstantina P. ; Kaltsatou, Antonia ; Mitrou, Georgia I. ; Jamurtas, Athanasios Z. ; Koutedakis, Yiannis ; Maridaki, Maria ; Stefanidis, Ioannis ; Sakkas, Giorgos K. ; Karatzaferi, Christina
Jankowski, Joachim
Subjects: Anemia ; Animals ; Antioxidants ; Antioxidants - metabolism ; Atherosclerosis ; Cardiovascular disease ; Colleges & universities ; Homeostasis ; Humans ; Hypertension ; Kidney - metabolism ; Kidney - physiopathology ; Kidney diseases ; Lipid Peroxidation ; Lipids ; Mortality ; Oxidation ; Oxidation-Reduction ; Oxidative Stress ; Peritoneal dialysis ; Physical education ; Prognosis ; Protein Carbonylation ; Proteins ; Reactive Oxygen Species - metabolism ; Renal Insufficiency, Chronic - metabolism ; Renal Insufficiency, Chronic - physiopathology ; Renal Insufficiency, Chronic - therapy ; Review ; Sport science ; Vitamin E
Is Part Of: Oxidative medicine and cellular longevity, 2016-01, Vol.2016, p.8598253-19
Description: Patients with chronic kidney disease (CKD) experience imbalance between oxygen reactive species (ROS) production and antioxidant defenses leading to cell and tissue damage. However, it remains unclear at which stage of renal insufficiency the redox imbalance becomes more profound. The aim of this systematic review was to provide an update on recent advances in our understanding of how the redox status changes in the progression of renal disease from predialysis stages 1 to 4 to end stage 5 and whether the various treatments and dialysis modalities influence the redox balance. A systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines. In total, thirty-nine studies met the inclusion criteria and were reviewed. Even from an early stage, imbalance in redox status is evident and as the kidney function worsens it becomes more profound. Hemodialysis therapy per se seems to negatively influence the redox status by the elevation of lipid peroxidation markers, protein carbonylation, and impairing erythrocyte antioxidant defense. However, other dialysis modalities do not so far appear to confer advantages. Supplementation with antioxidants might assist and should be considered as an early intervention to halt premature atherogenesis development at an early stage of CKD.
Publisher: United States: Hindawi Publishing Corporation
Language: English
Identifier: ISSN: 1942-0900
EISSN: 1942-0994
DOI: 10.1155/2016/8598253
PMID: 27563376
Source: MEDLINE
PubMed Central
Alma/SFX Local Collection
ProQuest Central

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Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review

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