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Prevalence of idiopathic normal pressure hydrocephalus: A prospective, population-based study

PloS one, 2019-05, Vol.14 (5), p.e0217705-e0217705 [Peer Reviewed Journal]

COPYRIGHT 2019 Public Library of Science ;COPYRIGHT 2019 Public Library of Science ;2019 Andersson et al 2019 Andersson et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0217705 ;PMID: 31141553

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Title:
Prevalence of idiopathic normal pressure hydrocephalus: A prospective, population-based study
Author: Andersson, Johanna ; Rosell, Michelle ; Kockum, Karin ; Lilja-Lund, Otto ; Söderström, Lars ; Laurell, Katarina
Burger, Michael C
Subjects: Aged ; Aged, 80 and over ; Analysis ; Biology and Life Sciences ; Care and treatment ; Dementia - epidemiology ; Dementia - physiopathology ; Female ; Gait - physiology ; Humans ; Hydrocephalus ; Hydrocephalus, Normal Pressure - epidemiology ; Hydrocephalus, Normal Pressure - physiopathology ; Incontinence ; Male ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Normal pressure hydrocephalus ; People and Places ; Prevalence ; Prevalence studies (Epidemiology) ; Prospective Studies ; Research and Analysis Methods ; Risk factors ; Surgery ; Urinary incontinence ; Urinary Incontinence - epidemiology ; Urinary Incontinence - physiopathology
Is Part Of: PloS one, 2019-05, Vol.14 (5), p.e0217705-e0217705
Description: Idiopathic normal pressure hydrocephalus (iNPH) causing gait impairment, dementia and urinary incontinence among the elderly, is probably under-diagnosed and under-treated. Despite being known since the 1960s, there is still a lack of prospective, population-based studies on the prevalence of iNPH. Such studies are warranted to minimize selection bias and estimate the true prevalence of the disease. The prevalence of iNPH was determined in a randomly selected sample of residents, aged 65 years and older, in the Swedish county of Jämtland. Out of 1,000 individuals invited to participate, 673 (67.3%) completed a questionnaire with seven questions on iNPH symptoms. A subgroup, with and without self-reported symptoms, participated in clinical and radiological evaluations and were diagnosed according to international guidelines. Measurement of cerebrospinal fluid opening pressure was not performed as it was considered too invasive. Those who reported at least two symptoms in the questionnaire (n = 117) and 51 randomly selected individuals with 0-1 symptom participated in further examinations. Out of them, 25 individuals received the diagnosis probable iNPH according to American-European guidelines (except for the criterion of CSF opening pressure) corresponding to a prevalence of 3.7%. The prevalence of iNPH was four times higher among those aged 80 years and older (8.9%) than among those aged 65-79 years (2.1%) (p <0.001). The difference in prevalence between men (4.6%) and women (2.9%) was not significant (p = 0.24). When iNPH was diagnosed according to the Japanese guidelines the prevalence was 1.5. In this prospective, population-based study the prevalence of iNPH was 3.7% among individuals 65 years and older, and more common in the higher age group, 80 years and above. INPH should be increasingly recognized since it is a fairly common condition and an important cause of gait impairment and dementia among the elderly that can be effectively treated by shunt surgery.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0217705
PMID: 31141553
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
SWEPUB Freely available online
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

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Prevalence of idiopathic normal pressure hydrocephalus: A prospective, population-based study

COPYRIGHT 2019 Public Library of Science ;COPYRIGHT 2019 Public Library of Science ;2019 Andersson et al 2019 Andersson et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0217705 ;PMID: 31141553

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