Language:

Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials And Research group database

Annals of the rheumatic diseases, 2007-06, Vol.66 (6), p.754-763 [Peer Reviewed Journal]

Copyright 2007 by Annals of the Rheumatic Diseases ;2007 INIST-CNRS ;Copyright: 2007 Copyright 2007 by Annals of the Rheumatic Diseases ;Copyright © 2007 BMJ Publishing Group and European League Against Rheumatism ;ISSN: 0003-4967 ;EISSN: 1468-2060 ;DOI: 10.1136/ard.2006.062901 ;PMID: 17234652 ;CODEN: ARDIAO

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials And Research group database
Author: Walker, U A ; Tyndall, A ; Czirják, L ; Denton, C ; Farge-Bancel, D ; Kowal-Bielecka, O ; Müller-Ladner, U ; Bocelli-Tyndall, C ; Matucci-Cerinic, M
Subjects: ACA ; ACR ; Adult ; Age Distribution ; Age of Onset ; Aged ; American College of Rheumatology ; anticentromere autoantibody ; Autoantibodies - blood ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; creatine kinase ; Cross-Sectional Studies ; Databases, Factual ; dcSSc ; Dermatology ; diffuse cutaneous systemic sclerosis ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; EULAR Scleroderma Trials And Research ; EUSTAR ; Extended Report ; Female ; Humans ; lcSSc ; limited cutaneous systemic scerosis ; Male ; Medical sciences ; Middle Aged ; Nuclear Proteins - immunology ; PAH ; pulmonary artery hypertension (assessed by echocardiography) ; Raynaud Disease - etiology ; Raynaud Disease - immunology ; Risk Assessment ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Scleroderma, Diffuse - complications ; Scleroderma, Diffuse - immunology ; Scleroderma, Limited - complications ; Scleroderma, Limited - immunology ; Scleroderma, Systemic - complications ; Scleroderma, Systemic - immunology ; Sex Factors ; SSc ; sytemic sclerosis ; Vascular disorders of the skin
Is Part Of: Annals of the rheumatic diseases, 2007-06, Vol.66 (6), p.754-763
Description: Background: Systemic sclerosis (SSc) is a multisystem autoimmune disease, which is classified into a diffuse cutaneous (dcSSc) and a limited cutaneous (lcSSc) subset according to the skin involvement. In order to better understand the vascular, immunological and fibrotic processes of SSc and to guide its treatment, the EULAR Scleroderma Trials And Research (EUSTAR) group was formed in June 2004. Aims and methods: EUSTAR collects prospectively the Minimal Essential Data Set (MEDS) on all sequential patients fulfilling the American College of Rheumatology diagnostic criteria in participating centres. We aimed to characterise demographic, clinical and laboratory characteristics of disease presentation in SSc and analysed EUSTAR baseline visits. Results: In April 2006, a total of 3656 patients (1349 with dcSSc and 2101 with lcSSc) were enrolled in 102 centres and 30 countries. 1330 individuals had autoantibodies against Scl70 and 1106 against anticentromere antibodies. 87% of patients were women. On multivariate analysis, scleroderma subsets (dcSSc vs lcSSc), antibody status and age at onset of Raynaud’s phenomenon, but not gender, were found to be independently associated with the prevalence of organ manifestations. Autoantibody status in this analysis was more closely associated with clinical manifestations than were SSc subsets. Conclusion: dcSSc and lcSSc subsets are associated with particular organ manifestations, but in this analysis the clinical distinction seemed to be superseded by an antibody-based classification in predicting some scleroderma complications. The EUSTAR MEDS database facilitates the analysis of clinical patterns in SSc, and contributes to the standardised assessment and monitoring of SSc internationally.
Publisher: London: BMJ Publishing Group Ltd and European League Against Rheumatism
Language: English
Identifier: ISSN: 0003-4967
EISSN: 1468-2060
DOI: 10.1136/ard.2006.062901
PMID: 17234652
CODEN: ARDIAO
Source: MEDLINE
PubMed Central
Alma/SFX Local Collection
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials And Research group database

Searching Remote Databases, Please Wait