Language:

Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis

Annals of the rheumatic diseases, 2012-07, Vol.71 (7), p.1235-1242 [Peer Reviewed Journal]

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;2015 INIST-CNRS ;Copyright: 2012 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;ISSN: 0003-4967 ;EISSN: 1468-2060 ;DOI: 10.1136/annrheumdis-2011-200955 ;PMID: 22586157 ;CODEN: ARDIAO

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis
Author: Khan, Korsa ; Xu, Shiwen ; Nihtyanova, Svetlana ; Derrett-Smith, Emma ; Abraham, David ; Denton, Christopher P ; Ong, Voon H
Subjects: Biological and medical sciences ; Biomarkers - blood ; Biopsy ; C-Reactive Protein - analysis ; Cardiovascular disease ; Cells, Cultured ; Dermis - drug effects ; Dermis - metabolism ; Dermis - pathology ; Diseases of the osteoarticular system ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - pathology ; Extracellular Matrix Proteins - metabolism ; Female ; Fibroblasts ; Fibroblasts - drug effects ; Fibroblasts - metabolism ; Fibroblasts - pathology ; Gene Expression ; Humans ; Interleukin-6 - blood ; Interleukin-6 - genetics ; Leukocytes, Mononuclear - metabolism ; Leukocytes, Mononuclear - pathology ; Male ; Medical prognosis ; Medical sciences ; Middle Aged ; Mortality ; Platelet Count ; Proteins ; Receptors, Interleukin-6 - blood ; Receptors, Interleukin-6 - genetics ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Scleroderma ; Scleroderma, Diffuse - blood ; Scleroderma, Diffuse - mortality ; Scleroderma, Diffuse - pathology ; Scleroderma, Limited - blood ; Scleroderma, Limited - mortality ; Scleroderma, Limited - pathology ; Signal Transduction ; Skin - metabolism ; Skin - pathology ; Survival Rate ; United Kingdom - epidemiology ; Wound healing
Is Part Of: Annals of the rheumatic diseases, 2012-07, Vol.71 (7), p.1235-1242
Description: Objective To determine the potential clinical and pathological significance of altered expression of interleukin 6 (IL-6) in systemic sclerosis (SSc). Methods Serum IL-6 and soluble IL-6 receptor levels were measured in patients with SSc (n=68) and healthy controls (n=15). Associations between serum IL-6 level and C reactive protein, platelet count and key clinical outcomes in SSc were explored. Expression of IL-6 in skin biopsies was also examined and western blot and reverse transcription PCRanalysis were performed using cultured dermal fibroblasts. The effect of IL-6 trans-signalling on production of extracellular matrix proteins was assessed and downstream signalling pathways were examined using pharmacological inhibitors. Results Serum IL-6 level was frequently elevated in patients with SSc, particularly in those with diffuse cutaneous SSc (dcSSc) with thrombocytosis and elevated acute phase markers. Prominent expression in the skin was observed in dermal fibroblasts, mononuclear cells and endothelial cells in patients with early dcSSc. In vitro experiments supported a potent profibrotic effect of IL-6 trans-signalling via the JAK2/STAT3 and ERK pathways. High IL-6 expression early in dcSSc appears to be associated with more severe skin involvement at 3 years and worse long-term survival than in those without elevated IL-6 levels. Conclusion Our results confirm the overexpression of IL-6 in dcSSc and support the potential of IL-6 as a surrogate marker for clinical outcome in this disease. The data also provide rationale for clinical studies targeting IL-6 trans-signalling as a potential antifibrotic therapy for SSc.
Publisher: London: BMJ Publishing Group Ltd and European League Against Rheumatism
Language: English
Identifier: ISSN: 0003-4967
EISSN: 1468-2060
DOI: 10.1136/annrheumdis-2011-200955
PMID: 22586157
CODEN: ARDIAO
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis

Searching Remote Databases, Please Wait