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Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people

The Lancet (British edition), 2014-05, Vol.383 (9932), p.1899-1911 [Peer Reviewed Journal]

Rapsomaniki et al. Open Access article distributed under the terms of CC BY ;2014 Rapsomaniki et al. Open Access article distributed under the terms of CC BY ;2015 INIST-CNRS ;Copyright © 2014 Rapsomaniki et al. Open Access article distributed under the terms of CC BY. Published by Elsevier Ltd. All rights reserved. ;Copyright Elsevier Limited May 31, 2014 ;2014 Rapsomaniki et al. Open Access article distributed under the terms of CC BY 2014 ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(14)60685-1 ;PMID: 24881994 ;CODEN: LANCAO

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Title:
Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people
Author: Rapsomaniki, Eleni, Dr ; Timmis, Adam, Prof ; George, Julie, PhD ; Pujades-Rodriguez, Mar, PhD ; Shah, Anoop D, MRCP ; Denaxas, Spiros, PhD ; White, Ian R, PhD ; Caulfield, Mark J, Prof ; Deanfield, John E, Prof ; Smeeth, Liam, Prof ; Williams, Bryan, Prof ; Hingorani, Aroon, Prof ; Hemingway, Harry, Prof
Subjects: Acute Disease ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Angina Pectoris - epidemiology ; Angina Pectoris - etiology ; Antihypertensive Agents - therapeutic use ; Aortic Aneurysm, Abdominal - epidemiology ; Aortic Aneurysm, Abdominal - etiology ; Biological and medical sciences ; Blood pressure ; Blood Pressure - physiology ; Cardiovascular disease ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - physiopathology ; Chronic Disease ; England - epidemiology ; Epidemiology ; Female ; Follow-Up Studies ; General aspects ; Health risk assessment ; Humans ; Hypertension - complications ; Hypertension - drug therapy ; Hypertension - epidemiology ; Incidence ; Internal Medicine ; Intracranial Hemorrhage, Hypertensive - epidemiology ; Male ; Medical Record Linkage ; Medical research ; Medical sciences ; Middle Aged ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Assessment - methods ; Studies ; Subarachnoid Hemorrhage - epidemiology ; Subarachnoid Hemorrhage - etiology
Is Part Of: The Lancet (British edition), 2014-05, Vol.383 (9932), p.1899-1911
Description: Summary Background The associations of blood pressure with the different manifestations of incident cardiovascular disease in a contemporary population have not been compared. In this study, we aimed to analyse the associations of blood pressure with 12 different presentations of cardiovascular disease. Methods We used linked electronic health records from 1997 to 2010 in the CALIBER (CArdiovascular research using LInked Bespoke studies and Electronic health Records) programme to assemble a cohort of 1·25 million patients, 30 years of age or older and initially free from cardiovascular disease, a fifth of whom received blood pressure-lowering treatments. We studied the heterogeneity in the age-specific associations of clinically measured blood pressure with 12 acute and chronic cardiovascular diseases, and estimated the lifetime risks (up to 95 years of age) and cardiovascular disease-free life-years lost adjusted for other risk factors at index ages 30, 60, and 80 years. This study is registered at ClinicalTrials.gov , number NCT01164371. Findings During 5·2 years median follow-up, we recorded 83 098 initial cardiovascular disease presentations. In each age group, the lowest risk for cardiovascular disease was in people with systolic blood pressure of 90–114 mm Hg and diastolic blood pressure of 60–74 mm Hg, with no evidence of a J-shaped increased risk at lower blood pressures. The effect of high blood pressure varied by cardiovascular disease endpoint, from strongly positive to no effect. Associations with high systolic blood pressure were strongest for intracerebral haemorrhage (hazard ratio 1·44 [95% CI 1·32–1·58]), subarachnoid haemorrhage (1·43 [1·25–1·63]), and stable angina (1·41 [1·36–1·46]), and weakest for abdominal aortic aneurysm (1·08 [1·00–1·17]). Compared with diastolic blood pressure, raised systolic blood pressure had a greater effect on angina, myocardial infarction, and peripheral arterial disease, whereas raised diastolic blood pressure had a greater effect on abdominal aortic aneurysm than did raised systolic pressure. Pulse pressure associations were inverse for abdominal aortic aneurysm (HR per 10 mm Hg 0·91 [95% CI 0·86–0·98]) and strongest for peripheral arterial disease (1·23 [1·20–1·27]). People with hypertension (blood pressure ≥140/90 mm Hg or those receiving blood pressure-lowering drugs) had a lifetime risk of overall cardiovascular disease at 30 years of age of 63·3% (95% CI 62·9–63·8) compared with 46·1% (45·5–46·8) for those with normal blood pressure, and developed cardiovascular disease 5·0 years earlier (95% CI 4·8–5·2). Stable and unstable angina accounted for most (43%) of the cardiovascular disease-free years of life lost associated with hypertension from index age 30 years, whereas heart failure and stable angina accounted for the largest proportion (19% each) of years of life lost from index age 80 years. Interpretation The widely held assumptions that blood pressure has strong associations with the occurrence of all cardiovascular diseases across a wide age range, and that diastolic and systolic associations are concordant, are not supported by the findings of this high-resolution study. Despite modern treatments, the lifetime burden of hypertension is substantial. These findings emphasise the need for new blood pressure-lowering strategies, and will help to inform the design of randomised trials to assess them. Funding Medical Research Council, National Institute for Health Research, and Wellcome Trust.
Publisher: Kidlington: Elsevier Ltd
Language: English
Identifier: ISSN: 0140-6736
EISSN: 1474-547X
DOI: 10.1016/S0140-6736(14)60685-1
PMID: 24881994
CODEN: LANCAO
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
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Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people

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