skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

TREK-1 in the heart: Potential physiological and pathophysiological roles

Frontiers in physiology, 2022, Vol.13 [Peer Reviewed Journal]

Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 1664-042X ;EISSN: 1664-042X ;DOI: 10.3389/fphys.2022.1095102

Full text available

Citations Cited by
  • Title:
    TREK-1 in the heart: Potential physiological and pathophysiological roles
  • Author: Bechard, Emilie ; Bride, Jamie ; Le Guennec, Jean-Yves ; Brette, Fabien ; Demion, Marie
  • Subjects: Cardiology and cardiovascular system ; Human health and pathology ; Life Sciences ; Tissues and Organs
  • Is Part Of: Frontiers in physiology, 2022, Vol.13
  • Description: The TREK-1 channel belongs to the TREK subfamily of two-pore domains channels that are activated by stretch and polyunsaturated fatty acids and inactivated by Protein Kinase A phosphorylation. The activation of this potassium channel must induce a hyperpolarization of the resting membrane potential and a shortening of the action potential duration in neurons and cardiac cells, two phenomena being beneficial for these tissues in pathological situations like ischemia-reperfusion. Surprisingly, the physiological role of TREK-1 in cardiac function has never been thoroughly investigated, very likely because of the lack of a specific inhibitor. However, possible roles have been unraveled in pathological situations such as atrial fibrillation worsened by heart failure, right ventricular outflow tract tachycardia or pulmonary arterial hypertension. The inhomogeneous distribution of TREK-1 channel within the heart reinforces the idea that this stretch-activated potassium channel might play a role in cardiac areas where the mechanical constraints are important and need a particular protection afforded by TREK-1. Consequently, the main purpose of this mini review is to discuss the possible role played by TREK -1 in physiological and pathophysiological conditions and its potential role in mechano-electrical feedback. Improved understanding of the role of TREK-1 in the heart may help the development of promising treatments for challenging cardiac diseases.
  • Publisher: Frontiers
  • Language: English
  • Identifier: ISSN: 1664-042X
    EISSN: 1664-042X
    DOI: 10.3389/fphys.2022.1095102
  • Source: Hyper Article en Ligne (HAL) (Open Access)
    GFMER Free Medical Journals
    NCBI PubMed Central（免费）
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait