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Uusia hydroksyyliryhmän sisältäviä 1,3-dialkyyliureajohdannaisia

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  • Title:
    Uusia hydroksyyliryhmän sisältäviä 1,3-dialkyyliureajohdannaisia
  • Author: FUJIMURA, KEN-ICHI ; MIYAWAKI, NOBUAKI ; KAWASHIMA, YOICHI ; SUHARA, HIROSHI ; FUJITA, YUKO
  • Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY
  • Description: The present invention relates to compounds represented by the formula ÄIÜ and salts thereof, wherein R and R each represents a carboxyl group which can be converted into ester, amide or hydroxamic acid; R represents a lower alkyl group or a phenyl-lower alkyl group; R represents a hydrogen atom, a lower alkyl group, an amino-lower alkyl group, a lower alkylamino-lower alkyl group, a hydroxy-lower alkyl group, a mercapto-lower alkyl group, a carboxy-lower alkyl group, a lower alkoxycarbonyl-lower alkyl group, an imidazolyl-lower alkyl group, an indolyl-lower alkyl group, (substituted) phenyl group, (substituted) phenyl-lower alkyl group, (substituted) naphtyl group, or (substituted) naphtyl-lower alkyl group. The compounds of the present invention have inhibitory effects on endopeptidase 24.11 and are useful as therapeutic agents for cardiovascular disease such as heart failure and hypertension, renal disease such as renal failure, gastroenteric disorder such as diarrhea and hyperchlorhydria, endocrine and metabolic disease such as obesity, and autoimmune disease such as rheumatism, and as analgestics for myosalgia, migraine.
  • Creation Date: 1996
  • Language: Finnish;Swedish
  • Source: esp@cenet
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