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Clustering of HR + /HER2- breast cancer in an Asian cohort is driven by immune phenotypes

Breast cancer research : BCR, 2024-04, Vol.26 (1), p.67-67 [Peer Reviewed Journal]

2024. The Author(s). ;COPYRIGHT 2024 BioMed Central Ltd. ;2024. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2024 ;ISSN: 1465-5411 ;EISSN: 1465-542X ;DOI: 10.1186/s13058-024-01826-5 ;PMID: 38649964

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Title:
Clustering of HR + /HER2- breast cancer in an Asian cohort is driven by immune phenotypes
Author: Pan, Jia-Wern ; Ragu, Mohana ; Chan, Wei-Qin ; Hasan, Siti Norhidayu ; Islam, Tania ; Teoh, Li-Ying ; Jamaris, Suniza ; See, Mee-Hoong ; Yip, Cheng-Har ; Rajadurai, Pathmanathan ; Looi, Lai-Meng ; Taib, Nur Aishah Mohd ; Rueda, Oscar M ; Caldas, Carlos ; Chin, Suet-Feung ; Lim, Joanna ; Teo, Soo-Hwang
Subjects: Adult ; Aged ; Analysis ; Asian people ; Asian People - genetics ; B cells ; Biomarkers, Tumor - genetics ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - immunology ; Breast Neoplasms - pathology ; Cancer ; Classification ; Classification schemes ; Cluster Analysis ; Clustering ; Cohort Studies ; Copy number ; DNA Copy Number Variations ; ErbB-2 protein ; Exome Sequencing ; Female ; Gene expression ; Gene Expression Profiling ; Genetic aspects ; Genomes ; Homologous recombination ; Humans ; Immune system ; Immunotherapy ; Malaysia - epidemiology ; Middle Aged ; Mutation ; Oncology, Experimental ; Patients ; Phenotype ; Phenotypes ; Receptor, ErbB-2 - genetics ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - genetics ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - genetics ; Receptors, Progesterone - metabolism ; Transcriptome ; Transcriptomics ; Tumors
Is Part Of: Breast cancer research : BCR, 2024-04, Vol.26 (1), p.67-67
Description: Breast cancer exhibits significant heterogeneity, manifesting in various subtypes that are critical in guiding treatment decisions. This study aimed to investigate the existence of distinct subtypes of breast cancer within the Asian population, by analysing the transcriptomic profiles of 934 breast cancer patients from a Malaysian cohort. Our findings reveal that the HR + /HER2- breast cancer samples display a distinct clustering pattern based on immune phenotypes, rather than conforming to the conventional luminal A-luminal B paradigm previously reported in breast cancers from women of European descent. This suggests that the activation of the immune system may play a more important role in Asian HR + /HER2- breast cancer than has been previously recognized. Analysis of somatic mutations by whole exome sequencing showed that counter-intuitively, the cluster of HR + /HER2- samples exhibiting higher immune scores was associated with lower tumour mutational burden, lower homologous recombination deficiency scores, and fewer copy number aberrations, implicating the involvement of non-canonical tumour immune pathways. Further investigations are warranted to determine the underlying mechanisms of these pathways, with the potential to develop innovative immunotherapeutic approaches tailored to this specific patient population.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1465-5411
EISSN: 1465-542X
DOI: 10.1186/s13058-024-01826-5
PMID: 38649964
Source: SpringerOpen
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Clustering of HR + /HER2- breast cancer in an Asian cohort is driven by immune phenotypes

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