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Systematic Review and Meta-analysis of Circulatory Disease from Exposure to Low-Level Ionizing Radiation and Estimates of Potential Population Mortality Risks

Environmental health perspectives, 2012-11, Vol.120 (11), p.1503-1511 [Peer Reviewed Journal]

2015 INIST-CNRS ;COPYRIGHT 2012 National Institute of Environmental Health Sciences ;COPYRIGHT 2012 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences Nov 2012 ;Distributed under a Creative Commons Attribution 4.0 International License ;2012 ;ISSN: 0091-6765 ;ISSN: 1552-9924 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.1204982 ;PMID: 22728254 ;CODEN: EVHPAZ

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Title:
Systematic Review and Meta-analysis of Circulatory Disease from Exposure to Low-Level Ionizing Radiation and Estimates of Potential Population Mortality Risks
Author: Little, Mark P. ; Azizova, Tamara V. ; Bazyka, Dimitry ; Bouffler, Simon D. ; Cardis, Elisabeth ; Chekin, Sergey ; Chumak, Vadim V. ; Cucinotta, Francis A. ; de Vathaire, Florent ; Hall, Per ; Harrison, John D. ; Hildebrandt, Guido ; Ivanov, Victor ; Kashcheev, Valeriy V. ; Klymenko, Sergiy V. ; Kreuzer, Michaela ; Laurent, Olivier ; Ozasa, Kotaro ; Schneider, Thierry ; Tapio, Soile ; Taylor, Andrew M. ; Tzoulaki, Ioanna ; Vandoolaeghe, Wendy L. ; Wakeford, Richard ; Zablotska, Lydia B. ; Zhang, Wei ; Lipshultz, Steven E.
Subjects: Analysis ; Cancer ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Circulation ; Complications and side effects ; Disease risk ; Dosage ; Dose-Response Relationship, Radiation ; Environmental Exposure ; Environmentally induced diseases ; Epidemiology ; Estimates ; Heart diseases ; Humans ; International Statistical Classification of Diseases ; Ionizing radiation ; Life Sciences ; Medicin och hälsovetenskap ; Meta-analysis ; Mortality ; Occupational ; Occupational Exposure ; Patient outcomes ; Population estimates ; Radiation dosage ; Radiation Injuries - epidemiology ; Radiation Injuries - etiology ; Radiation Injuries - mortality ; Radiation Monitoring ; Radiation, Ionizing ; Radiotherapy ; Review ; Reviews ; Risk ; Risk factors ; Searching
Is Part Of: Environmental health perspectives, 2012-11, Vol.120 (11), p.1503-1511
Description: Background: Although high doses of ionizing radiation have long been linked to circulatory disease, evidence for an association at lower exposures remains controversial. However, recent analyses suggest excess relative risks at occupational exposure levels. Objectives: We performed a systematic review and meta-analysis to summarize information on circulatory disease risks associated with moderate- and low-level whole-body ionizing radiation exposures. Methods: We conducted PubMed/ISI Thomson searches of peer-reviewed papers published since 1990 using the terms "radiation" AND "heart" AND "disease," OR "radiation" AND "stroke," OR "radiation" AND "circulatory" AND "disease." Radiation exposures had to be whole-body, with a cumulative mean dose of < 0.5 Sv, or at a low dose rate (< 10 mSv/day). We estimated population risks of circulatory disease from low-level radiation exposure using excess relative risk estimates from this meta-analysis and current mortality rates for nine major developed countries. Results: Estimated excess population risks for all circulatory diseases combined ranged from 2.5%/Sv [95% confidence interval (CI): 0.8, 4.2] for France to 8.5%/Sv (95% CI: 4.0, 13.0) for Russia. Conclusions: Our review supports an association between circulatory disease mortality and low and moderate doses of ionizing radiation. Our analysis was limited by heterogeneity among studies (particularly for noncardiac end points), the possibility of uncontrolled confounding in some occupational groups by lifestyle factors, and higher dose groups (> 0.5 Sv) generally driving the observed trends. If confirmed, our findings suggest that overall radiation-related mortality is about twice that currently estimated based on estimates for cancer end points alone (which range from 4.2% to 5.6%/Sv for these populations).
Publisher: Research Triangle Park, NC: National Institute of Environmental Health Sciences
Language: English;Russian
Identifier: ISSN: 0091-6765
ISSN: 1552-9924
EISSN: 1552-9924
DOI: 10.1289/ehp.1204982
PMID: 22728254
CODEN: EVHPAZ
Source: U.S. Government Documents
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MEDLINE
PubMed Central
SWEPUB Freely available online
ProQuest Central

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Systematic Review and Meta-analysis of Circulatory Disease from Exposure to Low-Level Ionizing Radiation and Estimates of Potential Population Mortality Risks

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