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Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study

Scientific reports, 2015-06, Vol.5 (1), p.11208-11208, Article 11208 [Peer Reviewed Journal]

Copyright Nature Publishing Group Jun 2015 ;Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep11208 ;PMID: 26084728

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Title:
Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study
Author: Day, Felix R ; Elks, Cathy E ; Murray, Anna ; Ong, Ken K ; Perry, John R B
Subjects: Adipose tissue ; Adolescent ; Adult ; Age Factors ; Angina ; Biological Specimen Banks ; Body composition ; Cardiovascular disease ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Child ; Cognitive ability ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - etiology ; Disease Susceptibility ; Female ; Health risk assessment ; Hormone replacement therapy ; Humans ; Male ; Menarche ; Menopause ; Mens health ; Middle Aged ; Minority & ethnic groups ; Patient Outcome Assessment ; Phenotype ; Puberty ; Risk Factors ; Self Report ; United Kingdom - epidemiology ; Womens health ; Young Adult
Is Part Of: Scientific reports, 2015-06, Vol.5 (1), p.11208-11208, Article 11208
Description: Early puberty timing is associated with higher risks for type 2 diabetes (T2D) and cardiovascular disease in women and therefore represents a potential target for early preventive interventions. We characterised the range of diseases and other adverse health outcomes associated with early or late puberty timing in men and women in the very large UK Biobank study. Recalled puberty timing and past/current diseases were self-reported by questionnaire. We limited analyses to individuals of White ethnicity (250,037 women; 197,714 men) and to disease outcomes with at least 500 cases (~ 0.2% prevalence) and we applied stringent correction for multiple testing (corrected threshold P < 7.48 × 10(-5)). In models adjusted for socioeconomic position and adiposity/body composition variables, both in women and men separately, earlier puberty timing was associated with higher risks for angina, hypertension and T2D. Furthermore, compared to the median/average group, earlier or later puberty timing in women or men was associated with higher risks for 48 adverse outcomes, across a range of cancers, cardio-metabolic, gynaecological/obstetric, gastrointestinal, musculoskeletal, and neuro-cognitive categories. Notably, both early and late menarche were associated with higher risks for early natural menopause in women. Puberty timing in both men and women appears to have a profound impact on later health.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/srep11208
PMID: 26084728
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study

Copyright Nature Publishing Group Jun 2015 ;Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep11208 ;PMID: 26084728

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