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Establishing and regulating the composition of cilia for signal transduction

Nature reviews. Molecular cell biology, 2019-07, Vol.20 (7), p.389-405 [Peer Reviewed Journal]

COPYRIGHT 2019 Nature Publishing Group ;Springer Nature Limited 2019. ;ISSN: 1471-0072 ;EISSN: 1471-0080 ;DOI: 10.1038/s41580-019-0116-4 ;PMID: 30948801

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Title:
Establishing and regulating the composition of cilia for signal transduction
Author: Nachury, Maxence V ; Mick, David U
Subjects: Animals ; Care and treatment ; Cell Movement - physiology ; Cellular signal transduction ; Cilia ; Cilia - genetics ; Cilia - metabolism ; Composition ; Cyclic AMP - genetics ; Cyclic AMP - metabolism ; Diffusion barriers ; Humans ; Intermediates ; Nucleotides ; Odorants ; Polycystic kidney disease ; Protein transport ; Protein Transport - physiology ; Proteins ; Proteome - genetics ; Proteome - metabolism ; Proteomes ; Risk factors ; Second Messenger Systems - physiology ; Second messengers ; Signal transduction ; Signaling ; Sterols
Is Part Of: Nature reviews. Molecular cell biology, 2019-07, Vol.20 (7), p.389-405
Description: The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that decodes a variety of signals - such as odorants, light and Hedgehog morphogens - by altering the local concentrations and activities of signalling proteins. Signalling within the cilium is conveyed through a diverse array of second messengers, including conventional signalling molecules (such as cAMP) and some unusual intermediates (such as sterols). Diffusion barriers at the ciliary base establish the unique composition of this signalling compartment, and cilia adapt their proteome to signalling demands through regulated protein trafficking. Much progress has been made on the molecular understanding of regulated ciliary trafficking, which encompasses not only exchanges between the cilium and the rest of the cell but also the shedding of signalling factors into extracellular vesicles.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-0072
EISSN: 1471-0080
DOI: 10.1038/s41580-019-0116-4
PMID: 30948801
Source: MEDLINE
ProQuest Central

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Establishing and regulating the composition of cilia for signal transduction

COPYRIGHT 2019 Nature Publishing Group ;Springer Nature Limited 2019. ;ISSN: 1471-0072 ;EISSN: 1471-0080 ;DOI: 10.1038/s41580-019-0116-4 ;PMID: 30948801

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