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Planar cell polarity in development and disease

Nature reviews. Molecular cell biology, 2017-06, Vol.18 (6), p.375-388 [Peer Reviewed Journal]

COPYRIGHT 2017 Nature Publishing Group ;COPYRIGHT 2017 Nature Publishing Group ;Copyright Nature Publishing Group Jun 2017 ;ISSN: 1471-0072 ;EISSN: 1471-0080 ;DOI: 10.1038/nrm.2017.11 ;PMID: 28293032

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Title:
Planar cell polarity in development and disease
Author: Butler, Mitchell T ; Wallingford, John B
Subjects: Animals ; Cell Polarity - genetics ; Cell Polarity - physiology ; Cell regulation ; Cellular control mechanisms ; Disease susceptibility ; Health aspects ; Humans ; Medical research ; Medicine, Experimental ; Morphogenesis ; Morphogenesis - genetics ; Morphogenesis - physiology ; Polarity (Biology) ; Protein Transport - genetics ; Protein Transport - physiology ; Signal Transduction - genetics ; Signal Transduction - physiology
Is Part Of: Nature reviews. Molecular cell biology, 2017-06, Vol.18 (6), p.375-388
Description: Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by multiple global cues, including gradients of gene expression, gradients of secreted WNT ligands and anisotropic tissue strain. These cues guide the dynamic, subcellular enrichment of PCP proteins, which can self-assemble into mutually exclusive complexes at opposite sides of a cell. Endocytosis, endosomal trafficking and degradation dynamics of PCP components further regulate planar tissue patterning. This polarization propagates throughout the whole tissue, providing a polarity axis that governs collective morphogenetic events such as the orientation of subcellular structures and cell rearrangements. Reflecting the necessity of polarized cellular behaviours for proper development and function of diverse organs, defects in PCP have been implicated in human pathologies, most notably in severe birth defects.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-0072
EISSN: 1471-0080
DOI: 10.1038/nrm.2017.11
PMID: 28293032
Source: AUTh Library subscriptions: ProQuest Central
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Planar cell polarity in development and disease

COPYRIGHT 2017 Nature Publishing Group ;COPYRIGHT 2017 Nature Publishing Group ;Copyright Nature Publishing Group Jun 2017 ;ISSN: 1471-0072 ;EISSN: 1471-0080 ;DOI: 10.1038/nrm.2017.11 ;PMID: 28293032

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