Language:

Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms

Journal of Neurology, 2020-08, Vol.267 (8), p.2179-2184 [Peer Reviewed Journal]

Springer-Verlag GmbH Germany, part of Springer Nature 2020 ;2020. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://www.springernature.com/gp/researchers/campaigns/coronavirus ;Springer-Verlag GmbH Germany, part of Springer Nature 2020. ;ISSN: 0340-5354 ;EISSN: 1432-1459 ;DOI: 10.1007/s00415-020-09929-7 ;PMID: 32458193

Digital Resources/Online E-Resources

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms
Author: Zhou, Zhiqiang ; Kang, Huicong ; Li, Shiyong ; Zhao, Xu
Subjects: ACE2 ; Angiotensin ; Angiotensin-converting enzyme 2 ; Animals ; Betacoronavirus ; Blood-Brain Barrier - metabolism ; Blood-Brain Barrier - pathology ; Blood-Brain Barrier - virology ; Brain - metabolism ; Brain - pathology ; Brain - virology ; Central nervous system ; Cerebrospinal fluid ; Cerebrovascular diseases ; Coronavirus Infections - diagnosis ; Coronavirus Infections - epidemiology ; Coronavirus Infections - metabolism ; Coronaviruses ; COVID-19 ; Dizziness - diagnosis ; Dizziness - epidemiology ; Dizziness - metabolism ; Encephalitis ; Encephalitis - diagnosis ; Encephalitis - epidemiology ; Encephalitis - metabolism ; Encephalopathy ; Glial cells ; Headache ; Headache - diagnosis ; Headache - epidemiology ; Headache - metabolism ; Hemorrhage ; Humans ; Ischemia ; Medicine ; Medicine & Public Health ; Meningitis ; Nervous System Diseases - diagnosis ; Nervous System Diseases - epidemiology ; Nervous System Diseases - metabolism ; Neurology ; Neuronal-glial interactions ; Neuroradiology ; Neurosciences ; Pandemics ; Peptidyl-dipeptidase A ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - metabolism ; Review ; Ribonucleic acid ; RNA ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Subarachnoid hemorrhage ; Thrombosis
Is Part Of: Journal of Neurology, 2020-08, Vol.267 (8), p.2179-2184
Description: Coronavirus disease 2019 (COVID-19), a disease caused by the novel betacoronavirus (SARS-CoV-2), has become a global pandemic threat. The potential involvement of COVID-19 in central nervous system (CNS) has attracted considerable attention due to neurological manifestations presented throughout the disease process. In addition, SARS-CoV-2 is structurally similar to SARS-CoV, and both bind to the angiotensin-converting enzyme 2 (ACE2) receptor to enter human cells. Thus, cells expressing ACE2, such as neurons and glial cells may act as targets and are thus vulnerable to SARS-CoV-2 infection. Here, we have reviewed the neurological characteristics of COVID-19 and summarized possible mechanisms of SARS-CoV-2 invasion of the CNS. COVID-19 patients have presented with a number of different neurological symptoms such as headache, dizziness, hyposmia, and hypogeusia during the course of illness. It has also been reported recently that some cases of COVID-19 have presented with concurrent acute cerebrovascular disease (acute ischemic stroke, cerebral venous sinus thrombosis, cerebral hemorrhage, subarachnoid hemorrhage), meningitis/encephalitis, acute necrotizing hemorrhagic encephalopathy, and acute Guillain–Barré syndrome. Furthermore, SARS-CoV-2 RNA detected in a cerebrospinal fluid specimen of a patient with COVID-19 have provided direct evidence to support the theory of neurotropic involvement of SARS-CoV-2. However, the underlying neurotropic mechanisms of SARS-CoV-2 are yet to be established. SARS-CoV-2 may affect CNS through two direct mechanisms (hematogenous dissemination or neuronal retrograde dissemination) or via indirect routes. The underlying mechanisms require further elucidation in the future.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 0340-5354
EISSN: 1432-1459
DOI: 10.1007/s00415-020-09929-7
PMID: 32458193
Source: Coronavirus Research Database

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms

Searching Remote Databases, Please Wait