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Selenium and its supplementation in cardiovascular disease--what do we know?

Nutrients, 2015-04, Vol.7 (5), p.3094-3118 [Peer Reviewed Journal]

Copyright MDPI AG 2015 ;2015 by the authors; licensee MDPI, Basel, Switzerland. 2015 ;ISSN: 2072-6643 ;EISSN: 2072-6643 ;DOI: 10.3390/nu7053094 ;PMID: 25923656

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  • Title:
    Selenium and its supplementation in cardiovascular disease--what do we know?
  • Author: Benstoem, Carina ; Goetzenich, Andreas ; Kraemer, Sandra ; Borosch, Sebastian ; Manzanares, William ; Hardy, Gil ; Stoppe, Christian
  • Subjects: Antioxidants - metabolism ; cardiac surgery ; cardiovascular disease ; Cardiovascular Diseases - diet therapy ; Cardiovascular Diseases - metabolism ; Cardiovascular System - metabolism ; coronary heart disease ; Dietary Supplements ; Humans ; Review ; Selenium - metabolism ; selenium selenoproteins ; Selenoproteins - metabolism ; Trace Elements - metabolism
  • Is Part Of: Nutrients, 2015-04, Vol.7 (5), p.3094-3118
  • Description: The trace element selenium is of high importance for many of the body's regulatory and metabolic functions. Balanced selenium levels are essential, whereas dysregulation can cause harm. A rapidly increasing number of studies characterizes the wide range of selenium dependent functions in the human body and elucidates the complex and multiple physiological and pathophysiological interactions of selenium and selenoproteins. For the majority of selenium dependent enzymes, several biological functions have already been identified, like regulation of the inflammatory response, antioxidant properties and the proliferation/differentiation of immune cells. Although the potential role of selenium in the development and progression of cardiovascular disease has been investigated for decades, both observational and interventional studies of selenium supplementation remain inconclusive and are considered in this review. This review covers current knowledge of the role of selenium and selenoproteins in the human body and its functional role in the cardiovascular system. The relationships between selenium intake/status and various health outcomes, in particular cardiomyopathy, myocardial ischemia/infarction and reperfusion injury are reviewed. We describe, in depth, selenium as a biomarker in coronary heart disease and highlight the significance of selenium supplementation for patients undergoing cardiac surgery.
  • Publisher: Switzerland: MDPI AG
  • Language: English
  • Identifier: ISSN: 2072-6643
    EISSN: 2072-6643
    DOI: 10.3390/nu7053094
    PMID: 25923656
  • Source: PubMed
    Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
    DOAJ Directory of Open Access Journals
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