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New insights into the multidimensional concept of macrophage ontogeny, activation and function

Nature immunology, 2016-01, Vol.17 (1), p.34-40 [Peer Reviewed Journal]

COPYRIGHT 2016 Nature Publishing Group ;COPYRIGHT 2016 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2016 ;ISSN: 1529-2908 ;EISSN: 1529-2916 ;DOI: 10.1038/ni.3324 ;PMID: 26681460

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  • Title:
    New insights into the multidimensional concept of macrophage ontogeny, activation and function
  • Author: Ginhoux, Florent ; Schultze, Joachim L ; Murray, Peter J ; Ochando, Jordi ; Biswas, Subhra K
  • Subjects: Animals ; Biological control systems ; Health aspects ; Humans ; Immune response ; Macrophage Activation - immunology ; Macrophages ; Medical research ; Medicine, Experimental
  • Is Part Of: Nature immunology, 2016-01, Vol.17 (1), p.34-40
  • Description: Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke changes in macrophage function that are causative of disease. Despite a historical wealth of knowledge about macrophages, recent advances have revealed unknown aspects of their development and function. Following development, macrophages are activated by diverse signals. Such tissue microenvironmental signals together with epigenetic changes influence macrophage development, activation and functional diversity, with consequences in disease and homeostasis. We discuss here how recent discoveries in these areas have led to a multidimensional concept of macrophage ontogeny, activation and function. In connection with this, we also discuss how technical advances facilitate a new roadmap for the isolation and analysis of macrophages at high resolution.
  • Publisher: United States: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 1529-2908
    EISSN: 1529-2916
    DOI: 10.1038/ni.3324
    PMID: 26681460
  • Source: AUTh Library subscriptions: ProQuest Central
    MEDLINE
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