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Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury

Circulation research, 2017-01, Vol.120 (2), p.381-399 [Tạp chí có phản biện]

2017 American Heart Association, Inc. ;Copyright Lippincott Williams & Wilkins Ovid Technologies Jan 20, 2017 ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.116.308434 ;PMID: 28104771

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Nhan đề:
Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury
Tác giả: Viereck, Janika ; Thum, Thomas
Chủ đề: Animals ; Biomarkers - blood ; Cardiovascular disease ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - genetics ; Coronary artery disease ; Genomes ; Heart diseases ; Humans ; MicroRNAs - blood ; MicroRNAs - genetics ; miRNA ; RNA, Long Noncoding - blood ; RNA, Long Noncoding - genetics ; RNA, Untranslated - blood ; RNA, Untranslated - genetics
Là 1 phần của: Circulation research, 2017-01, Vol.120 (2), p.381-399
Mô tả: The discovery of thousands of noncoding RNAs (ncRNAs) has expanded our view on mammalian genomes and transcriptomes, as well as their organization and regulation. Accumulating evidence on aberrantly regulated ncRNAs, including short microRNAs, long ncRNAs and circular RNAs, across various heart diseases indicates that ncRNAs are critical contributors to cardiovascular pathophysiology. In addition, ncRNAs are released into the circulation where they are present in concentration levels that differ between healthy subjects and diseased patients. Although little is known about the origin and function of such circulating ncRNAs, these molecules are increasingly recognized as noninvasive and readily accessible biomarker for risk stratification, diagnosis and prognosis of cardiac injury, and multiple forms of cardiovascular disease. In this review, we summarize recent findings on biological characteristics of circulating ncRNAs and highlight their value as potential biomarker in selected pathologies of cardiovascular disease.
Nơi xuất bản: United States: American Heart Association, Inc
Ngôn ngữ: English
Số nhận dạng: ISSN: 0009-7330
EISSN: 1524-4571
DOI: 10.1161/CIRCRESAHA.116.308434
PMID: 28104771
Nguồn: Freely Accessible Journals
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Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury

2017 American Heart Association, Inc. ;Copyright Lippincott Williams & Wilkins Ovid Technologies Jan 20, 2017 ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.116.308434 ;PMID: 28104771

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