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A case of cutaneous necrosis due to intra-articular hyaluronic acid and treated with hyaluronidase

SAGE open medical case reports, 2021, Vol.9, p.2050313-2050313X211025110 [Peer Reviewed Journal]

The Author(s) 2021 ;The Author(s) 2021. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2021 2021 SAGE Publications ;ISSN: 2050-313X ;EISSN: 2050-313X ;DOI: 10.1177/2050313X211025110 ;PMID: 34262769

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  • Title:
    A case of cutaneous necrosis due to intra-articular hyaluronic acid and treated with hyaluronidase
  • Author: Aaron, Michelle ; Qing Huang, Yu ; Bouffard, Danielle ; Costa, Jean-Pascal ; Côté, Benoît
  • Subjects: Embolisms ; Hyaluronic acid
  • Is Part Of: SAGE open medical case reports, 2021, Vol.9, p.2050313-2050313X211025110
  • Description: A 66-year-old woman presented to the hospital with cutaneous necrosis of her right ankle and foot. Her symptoms began immediately after an intra-articular injection of hyaluronic acid for ankle osteoarthritis, which was performed 6 days before. Histopathology showed an intra-vascular hyaluronic acid embolus. The initial treatment approach was conservative, but the patient’s clinical state degraded. She was thus treated with sub-cutaneous hyaluronidase, the enzyme that degrades hyaluronic acid, which yielded a moderate improvement even though it was administered 22 days after the initial hyaluronic acid injection. Although hyaluronic acid embolism and subsequent cutaneous necrosis are well-known complications of dermal fillers, there are few reported cases of embolism following intra-articular injection. To our knowledge, this is the first time hyaluronidase has been used in this setting.
  • Publisher: London, England: SAGE Publications
  • Language: English
  • Identifier: ISSN: 2050-313X
    EISSN: 2050-313X
    DOI: 10.1177/2050313X211025110
    PMID: 34262769
  • Source: Sage Journals Open Access
    Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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