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Time Lines of Infection and Disease in Human Influenza: A Review of Volunteer Challenge Studies

American journal of epidemiology, 2008-04, Vol.167 (7), p.775-785 [Peer Reviewed Journal]

American Journal of Epidemiology © 2008 The Authors 2008 ;2008 INIST-CNRS ;American Journal of Epidemiology © 2008 The Authors ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0002-9262 ;EISSN: 1476-6256 ;DOI: 10.1093/aje/kwm375 ;PMID: 18230677 ;CODEN: AJEPAS

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Title:
Time Lines of Infection and Disease in Human Influenza: A Review of Volunteer Challenge Studies
Author: Carrat, Fabrice ; Vergu, Elisabeta ; Ferguson, Neil M. ; Lemaitre, Magali ; Cauchemez, Simon ; Leach, Steve ; Valleron, Alain-Jacques
Subjects: Analysis. Health state ; Biological and medical sciences ; Computer Science ; Disease transmission ; Epidemiology ; General aspects ; human ; Human viral diseases ; Humans ; Infectious diseases ; Influenza ; Influenza A Virus, H1N1 Subtype - pathogenicity ; Influenza A Virus, H3N2 Subtype - pathogenicity ; Influenza B virus - pathogenicity ; Influenza Vaccines ; Influenza virus ; Influenza, Human - epidemiology ; Influenza, Human - immunology ; Influenza, Human - prevention & control ; Mathematics ; Medical sciences ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; signs and symptoms ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases ; Virology ; Virus Shedding
Is Part Of: American journal of epidemiology, 2008-04, Vol.167 (7), p.775-785
Description: The dynamics of viral shedding and symptoms following influenza virus infection are key factors when considering epidemic control measures. The authors reviewed published studies describing the course of influenza virus infection in placebo-treated and untreated volunteers challenged with wild-type influenza virus. A total of 56 different studies with 1,280 healthy participants were considered. Viral shedding increased sharply between 0.5 and 1 day after challenge and consistently peaked on day 2. The duration of viral shedding averaged over 375 participants was 4.80 days (95% confidence interval: 4.31, 5.29). The frequency of symptomatic infection was 66.9% (95% confidence interval: 58.3, 74.5). Fever was observed in 37.0% of A/H1N1, 40.6% of A/H3N2 (p = 0.86), and 7.5% of B infections (p = 0.001). The total symptoms scores increased on day 1 and peaked on day 3. Systemic symptoms peaked on day 2. No such data exist for children or elderly subjects, but epidemiologic studies suggest that the natural history might differ. The present analysis confirms prior expert opinion on the duration of viral shedding or the frequency of asymptomatic influenza infection, extends prior knowledge on the dynamics of viral shedding and symptoms, and provides original results on the frequency of respiratory symptoms or fever.
Publisher: Cary, NC: Oxford University Press
Language: English
Identifier: ISSN: 0002-9262
EISSN: 1476-6256
DOI: 10.1093/aje/kwm375
PMID: 18230677
CODEN: AJEPAS
Source: Hyper Article en Ligne (HAL) (Open Access)
GFMER Free Medical Journals
MEDLINE
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Time Lines of Infection and Disease in Human Influenza: A Review of Volunteer Challenge Studies

American Journal of Epidemiology © 2008 The Authors 2008 ;2008 INIST-CNRS ;American Journal of Epidemiology © 2008 The Authors ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0002-9262 ;EISSN: 1476-6256 ;DOI: 10.1093/aje/kwm375 ;PMID: 18230677 ;CODEN: AJEPAS

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