skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Uric Acid Predicts Weight and Cardiometabolic Outcomes Over 6-Year Follow-Up

Obesity (Silver Spring, Md.), 2021-12, Vol.29, p.185-186 [Peer Reviewed Journal]

Copyright Blackwell Publishing Ltd. Dec 2021 ;ISSN: 1930-7381 ;EISSN: 1930-739X

Full text available

Citations Cited by
  • Title:
    Uric Acid Predicts Weight and Cardiometabolic Outcomes Over 6-Year Follow-Up
  • Author: Corso, Lauren ; Wing, Rena ; Tate, Deborah ; Espeland, Mark ; Blanchard, Bruce ; Mccaffery, Jeanne
  • Subjects: Uric acid ; Young adults
  • Is Part Of: Obesity (Silver Spring, Md.), 2021-12, Vol.29, p.185-186
  • Description: Background: Few trials have examined uric acid (UA) as a predictor of weight gain and early cardiometabolic risk in young adults, an age group that is highly susceptible to weight gain. Methods: This study examined UA as a predictor of weight and cardiometabolic health outcomes in the Study of Novel Approaches to Weight Gain Prevention (SNAP) trial. SNAP randomized participants to small (100 kcal/d deficit +2,000 steps/d) or large (2.3-4.5 kg loss, 500-100 kcal/d + 250 min/wk exercise to maintain loss/prevent gain) changes or a self-guided control. Blood samples were analyzed for cardiometabolic outcomes and UA via spectrophotometric methods at baseline, 2-, and 6-year follow-up, using multiple linear regressions accounting for age, sex, baseline weight, clinic, baseline of the cardiometabolic variable, and treatment arm. Results: Participants (N = 297) were predominantly young (28.6 [4.4] years), female (76.4%, N = 227), of normal or overweight (BMI = 25.6 [2.5] kg/m2) and metabolically healthy. There were no differences in UA by treatment arm at baseline (p = 0.299), 2-years (p = 0.540) or 6-years (p = 0.566). Higher baseline UA was associated with less favorable BMI (p = 0.027), triglycerides (p < 0.001), HDL (p = 0.002), glucose (p = 0.042), insulin (p < 0.001) and HOMA (p < 0.001), independent of covariates over 2-and 6-year follow-up. Additionally, weight loss from baseline to 2-years was associated with changes in UA over this same time period; at least 1% weight loss from baseline to 2-years was associated with lower UA at 2-years compared to weight stable (-9.01 µmol/L versus +19.6 µmol/L, p = 0.009), or at least 1% weight gain (-9.0 µmol/L versus +15.9 µmol/L, p = 0.001). Similar trends were observed at 6-years. Conclusions: UA is a promising biomarker for clinical screens to identify individuals at-risk for future cardiometabolic dysfunction, weight gain, and progression to type 2 diabetes in young adults.
  • Publisher: Silver Spring: Blackwell Publishing Ltd
  • Language: English
  • Identifier: ISSN: 1930-7381
    EISSN: 1930-739X
  • Source: ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait