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Evaluation of cutaneous manifestations in patients under treatment with thyroid disease/Tedavi altindaki tiroid hastalarinda deri bulgularinin degerlendirilmesi

Türkderm, 2020-06, Vol.54 (2), p.46 [Peer Reviewed Journal]

COPYRIGHT 2020 Galenos Yayinevi Tic. Ltd. ;ISSN: 1019-214X ;EISSN: 2651-5164 ;DOI: 10.4274/turkderm.galenos.2020.04742

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  • Title:
    Evaluation of cutaneous manifestations in patients under treatment with thyroid disease/Tedavi altindaki tiroid hastalarinda deri bulgularinin degerlendirilmesi
  • Author: Acer, Ersoy ; Agaoglu, Esra ; Yorulmaz, Goknur ; Erdogan, Hilal Kaya ; Alaguney, Elif Sevil ; Saracoglu, Zeynep Nurhan ; Bilgin, Muzaffer
  • Subjects: Care and treatment ; Complications and side effects ; Cutaneous manifestations of general diseases ; Diagnosis ; Risk factors ; Thyroid diseases
  • Is Part Of: Türkderm, 2020-06, Vol.54 (2), p.46
  • Description: Background and Design: Thyroid diseases often cause various findings in hair, skin and nails. Some of them may be regressed by the treatment of thyroid disease. We aimed to evaluate the cutaneous manifestations in patients with thyroid disease under treatment. Materials and Methods: This cross-sectional study included 97 consecutive patients with thyroid disease under treatment and 50 healthy controls. Thyroid disease was classiffied as autoimmune and non-autoimmune. All skin findings and dermatological diseases were recorded. Results: Of the patient group, 56 (57.7%) had autoimmune, 41 (43.3%) had non-autoimmune thyroid disease. Eighty-four (86.4%) patients were under thyroid hormone therapy and 13 (23.6%) patients were under anti-thyroid therapy. 73.2% of the autoimmune group, 71.4% of non-autoimmune group and 52% of the control group had at least one cutaneous manifestation (p=0.05). Xerosis (p=0.026), pruritus (p=0.00), facial erythema (p=0.036), flushing (p=0.004), dry hair (p=0.008), brittle nails (p=0.02), dry nails (p=0.013) and longitudinal streaking on nails (p=0.02) were more frequent in the autoimmune group than in the non-autoimmune and control group. Alopecia (p=0.00) was more frequent in the non-autoimmune group. Furthermore diffuse hyperhidrosis (p=0.016), thinning of nails (p=0.059) and rosacea disease (p=0.03) were more common in the patient group than in the control group. At least one cutaneous manifestation, xerosis and various nail findings were more common in patients under thyroid hormone therapy than in patients under anti-thyroid therapy, but there was no statistically significant difference. Conclusion: These findings have shown that various cutaneous manifestations can also be seen in patients with thyroid disease under treatment. We believe that further studies comparing thyroid patients who received and did not receive treatment are necessary to clarify the effect of thyroid disease treatment on cutaneous manifestations. Keywords: Cutaneous manifestations, thyroid diseases, autoimmunity Amac: Tiroid hastaliklari siklikla sac, deri ve tirnaklarda cesitli bulgulara neden olur. Bu bulgularin bazilari tiroid hastaliginin tedavisi ile gerileyebilir. Bu calismada tedavi altindaki tiroid hastalarinda deri bulgularini degerlendirmeyi amacladik. Gerec ve Yontem: Bu kesitsel calismaya tedavi altindaki 97 tiroid hastasi ve 50 saglikli kontrol dahil edildi. Tiroid hastaligi otoimmun ve nonotoimmun olarak siniflandirildi. Tum deri bulgulari ve dermatolojik hastaliklar kaydedildi. Bulgular: Hasta grubunun 56'sinda (%57,7) otoimmun, 41'inde (%43,3) non-otoimmun tiroid hastaligi mevcuttu. Seksen dort (%86,4) hasta tiroid hormon tedavisi, 13 (%23,6) hasta anti-tiroid tedavi aliyordu. Otoimmun grubun %73,2'sinde, non-otoimmun grubun %71,4'unde ve kontrol grubunun %52'sinde en az bir deri bulgusu vardi (p=0,05). Kseroz (p=0,026), kasinti (p=0,00), fasiyal eritem (p=0,036), flushing (p=0,004), kuru sac (p=0,008), kirilgan tirnaklar (p=0,02), kuru tirnaklar (p=0,013) ve tirnaklarda uzunlamasina cizgiler (p=0,02) otoimmun grupta non-otoimmun ve kontrol grubuna gore daha sikti. Alopesi (p=0,00) non-otoimmun grupta daha sikti. Ayrica, hasta grubunda diffuz hiperhidroz (p=0,016), tirnaklarda incelme (p=0,059) ve rozase hastaligi (p=0,03) kontrol grubundan daha sikti. Tiroid hormon tedavisi alanlarda, en az bir deri bulgusu, kserozis ve cesitli tirnak bulgulari anti-tiroid tedavi alanlara gore daha sikti. Ancak istatistiksel olarak anlamli bir fark yoktu. Sonuc: Bu bulgular, tedavi altindaki tiroid hastalarinda da cesitli deri bulgularinin gorulebilecegini gostermistir. Tiroid hastaligi tedavisinin kutanoz bulgular uzerindeki etkisini netlestirmek icin tedavi altinda olan ve olmayan tiroid hastalarini karsilastiran daha ileri calismalarin gerekli oldugu dusunuyoruz. Anahtar Kelimeler: Kutanoz bulgular, tiroid hastaliklari, otoimmunite
  • Publisher: Galenos Yayinevi Tic. Ltd
  • Language: Turkish
  • Identifier: ISSN: 1019-214X
    EISSN: 2651-5164
    DOI: 10.4274/turkderm.galenos.2020.04742
  • Source: Directory of Open Access Journals
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