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Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial

BMJ, 2010-11, Vol.341 (7787), p.36-36 [Peer Reviewed Journal]

Galan et al 2010 ;2010 BMJ Publishing Group Ltd ;Copyright: 2010 (c) Galan et al 2010 ;Distributed under a Creative Commons Attribution 4.0 International License ;Galan et al 2010 2010 Galan et al ;ISSN: 0959-8138 ;ISSN: 0007-1447 ;EISSN: 1468-5833 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.c6273 ;PMID: 21115589

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Title:
Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial
Author: Galan, Pilar ; Kesse-Guyot, Emmanuelle ; Czernichow, Sébastien ; Briancon, Serge ; Blacher, Jacques ; Hercberg, Serge
Subjects: Aged ; Aged, 80 and over ; Angina, Unstable - diet therapy ; Biomarkers - blood ; Cardiovascular diseases ; Cardiovascular Diseases - prevention & control ; Clinical Trials (Epidemiology) ; Diet ; Dietary Supplements ; Disease risk ; Double-Blind Method ; Drugs: Cardiovascular System ; Experimentation ; Fatty acids ; Fatty Acids, Omega-6 - administration & dosage ; Fatty Acids, Omega-6 - blood ; Female ; Humans ; Ischaemic Heart Disease ; Kaplan-Meier Estimate ; Life Sciences ; Male ; Middle Aged ; Myocardial infarction ; Myocardial Infarction - diet therapy ; Myocardial ischemia ; Patient Compliance ; Placebos ; Stroke ; Stroke - diet therapy ; Strokes ; Treatment Outcome ; Vitamin B ; Vitamin B Complex - administration & dosage ; Vitamin B Complex - blood ; Vitamins and Supplements
Is Part Of: BMJ, 2010-11, Vol.341 (7787), p.36-36
Description: Objective To investigate whether dietary supplementation with B vitamins or omega 3 fatty acids, or both, could prevent major cardiovascular events in patients with a history of ischaemic heart disease or stroke.Design Double blind, randomised, placebo controlled trial; factorial design.Setting Recruitment throughout France via a network of 417 cardiologists, neurologists, and other physicians.Participants 2501 patients with a history of myocardial infarction, unstable angina, or ischaemic stroke.Intervention Daily dietary supplement containing 5-methyltetrahydrofolate (560 μg), vitamin B-6 (3 mg), and vitamin B-12 (20 μg) or placebo; and containing omega 3 fatty acids (600 mg of eicosapentanoic acid and docosahexaenoic acid at a ratio of 2:1) or placebo. Median duration of supplementation was 4.7 years.Main outcome measures Major cardiovascular events, defined as a composite of non-fatal myocardial infarction, stroke, or death from cardiovascular disease.Results Allocation to B vitamins lowered plasma homocysteine concentrations by 19% compared with placebo, but had no significant effects on major vascular events (75 v 82 patients, hazard ratio, 0.90 (95% confidence interval 0.66 to 1.23, P=0.50)). Allocation to omega 3 fatty acids increased plasma concentrations of omega 3 fatty acids by 37% compared with placebo, but also had no significant effect on major vascular events (81 v 76 patients, hazard ratio 1.08 (0.79 to 1.47, P=0.64)).Conclusion This study does not support the routine use of dietary supplements containing B vitamins or omega 3 fatty acids for prevention of cardiovascular disease in people with a history of ischaemic heart disease or ischaemic stroke, at least when supplementation is introduced after the acute phase of the initial event.Trial registration Current Controlled Trials ISRCTN41926726.
Publisher: England: British Medical Journal Publishing Group
Language: English
Identifier: ISSN: 0959-8138
ISSN: 0007-1447
EISSN: 1468-5833
EISSN: 1756-1833
DOI: 10.1136/bmj.c6273
PMID: 21115589
Source: BMJ Open Access Journals
MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial

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