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A Case-Control Study to Estimate the Effectiveness of Maternal Pertussis Vaccination in Protecting Newborn Infants in England and Wales, 2012–2013

Clinical infectious diseases, 2015-02, Vol.60 (3), p.333-337 [Peer Reviewed Journal]

Copyright © 2015 Oxford University Press on behalf of the Infectious Diseases Society of America ;Crown copyright 2014. ;ISSN: 1058-4838 ;EISSN: 1537-6591 ;DOI: 10.1093/cid/ciu821 ;PMID: 25332078

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  • Title:
    A Case-Control Study to Estimate the Effectiveness of Maternal Pertussis Vaccination in Protecting Newborn Infants in England and Wales, 2012–2013
  • Author: Dabrera, Gavin ; Amirthalingam, Gayatri ; Andrews, Nick ; Campbell, Helen ; Ribeiro, Sonia ; Kara, Edna ; Fry, Norman K. ; Ramsay, Mary
  • Subjects: ARTICLES AND COMMENTARIES ; Case-Control Studies ; Disease prevention ; Effectiveness studies ; England ; Female ; Humans ; Immunization ; Infant ; Infant, Newborn ; Male ; Newborn babies ; Pediatrics ; Pertussis Vaccine ; Polymerase chain reaction ; Pregnancy ; Real-Time Polymerase Chain Reaction ; Vaccination ; Wales ; Whooping cough ; Whooping Cough - prevention & control
  • Is Part Of: Clinical infectious diseases, 2015-02, Vol.60 (3), p.333-337
  • Description: Background. Infants with pertussis infection are at risk of severe clinical illness and death. Several countries, including the United Kingdom, have introduced maternal pertussis vaccination during pregnancy to protect infants from infection following national increases in pertussis notifications. The objective of this study was to estimate the effectiveness of maternal pertussis vaccination in protecting infants against laboratory-confirmed pertussis infection. Methods. A case-control study was undertaken in England and Wales between October 2012 and July 2013. Cases were infants aged <8 weeks at onset with pertussis infection tested by real-time polymerase chain reaction or culture. Family doctors of each case were asked to identify healthy infants born consecutively after the case in each practice, to act as controls. Fifty-eight cases and 55 controls were included in this study. Odds ratios (ORs) were calculated for the association between maternal vaccination and infant pertussis infection. The vaccine effectiveness (VE) was calculated as 1 – OR. This was adjusted for sex, geographical region, and birth period. Results. Mothers of 10 cases (17%) and 39 controls (71%) received pertussis vaccine in pregnancy. This gave an unadjusted VE of 91% (95% confidence interval [CI], 77%–97%). Adjusted VE was 93% (95% CI, 81%–97%). Conclusions. Maternal pertussis vaccination is effective in preventing pertussis infection in infants aged <8 weeks and may be considered in other countries experiencing high levels of pertussis notifications.
  • Publisher: United States: Oxford University Press
  • Language: English
  • Identifier: ISSN: 1058-4838
    EISSN: 1537-6591
    DOI: 10.1093/cid/ciu821
    PMID: 25332078
  • Source: MEDLINE
    Alma/SFX Local Collection
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