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Iron Overload Cardiomyopathy: Better Understanding of an Increasing Disorder

Journal of the American College of Cardiology, 2010-09, Vol.56 (13), p.1001-1012 [Peer Reviewed Journal]

2015 INIST-CNRS ;Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Sep 21, 2010 ;2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. 2010 ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2010.03.083 ;PMID: 20846597 ;CODEN: JACCDI

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Title:
Iron Overload Cardiomyopathy: Better Understanding of an Increasing Disorder
Author: GUJJA, Pradeep ; ROSING, Douglas R ; TRIPODI, Dorothy J ; SHIZUKUDA, Yukitaka
Subjects: Biological and medical sciences ; Biomarkers - blood ; Biopsy ; Blood ; Cardiology. Vascular system ; Cardiomyopathies - blood ; Cardiomyopathies - diagnosis ; Cardiomyopathies - etiology ; Cardiomyopathies - therapy ; Cardiomyopathy ; Critical Pathways ; Echocardiography ; Free radicals ; Heart ; Heart failure ; Homeostasis ; Humans ; Iron - physiology ; Iron Overload - blood ; Iron Overload - complications ; Iron Overload - diagnosis ; Iron Overload - therapy ; Ischemia ; Liver diseases ; Magnetic Resonance Imaging ; Medical sciences ; Metabolic diseases ; Metals (hemochromatosis...) ; Mortality ; Mutation ; Myocarditis. Cardiomyopathies ; Myocardium - pathology ; Other metabolic disorders ; Rodents ; Sickle cell disease ; Tomography, X-Ray Computed ; Transplants & implants
Is Part Of: Journal of the American College of Cardiology, 2010-09, Vol.56 (13), p.1001-1012
Description: The prevalence of iron overload cardiomyopathy (IOC) is increasing. The spectrum of symptoms of IOC is varied. Early in the disease process, patients may be asymptomatic, whereas severely overloaded patients can have terminal heart failure complaints that are refractory to treatment. It has been shown that early recognition and intervention may alter outcomes. Biochemical markers and tissue biopsy, which have traditionally been used to diagnose and guide therapy, are not sensitive enough to detect early cardiac iron deposition. Newer diagnostic modalities such as magnetic resonance imaging are noninvasive and can assess quantitative cardiac iron load. Phlebotomy and chelating drugs are suboptimal means of treating IOC; hence, the roles of gene therapy, hepcidin, and calcium channel blockers are being actively investigated. There is a need for the development of clinical guidelines in order to improve the management of this emerging complex disease.
Publisher: New York, NY: Elsevier
Language: English
Identifier: ISSN: 0735-1097
EISSN: 1558-3597
DOI: 10.1016/j.jacc.2010.03.083
PMID: 20846597
CODEN: JACCDI
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

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Iron Overload Cardiomyopathy: Better Understanding of an Increasing Disorder

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