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The Function and Therapeutic Potential of Circular RNA in Cardiovascular Diseases

Cardiovascular drugs and therapy, 2023-02, Vol.37 (1), p.181-198 [Peer Reviewed Journal]

Springer Science+Business Media, LLC, part of Springer Nature 2021 ;2021. Springer Science+Business Media, LLC, part of Springer Nature. ;Springer Science+Business Media, LLC, part of Springer Nature 2021. ;ISSN: 0920-3206 ;EISSN: 1573-7241 ;DOI: 10.1007/s10557-021-07228-5 ;PMID: 34269929

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Title:
The Function and Therapeutic Potential of Circular RNA in Cardiovascular Diseases
Author: Wang, Kai ; Gao, Xiang-Qian ; Wang, Tao ; Zhou, Lu-Yu
Subjects: Adapter proteins ; Apoptosis ; Binding sites ; Biomarkers ; Biosynthesis ; Cardiology ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - therapy ; Circular RNA ; Closed loops ; Cytoplasm ; Gene expression ; Growth factors ; Health services ; Heart Diseases ; Humans ; Hypertension ; Kinases ; Medical diagnosis ; Medical treatment ; Medicine ; Medicine & Public Health ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - therapeutic use ; miRNA ; Peptides ; Prevention ; Review Article ; Ribonucleic acid ; RNA ; RNA - genetics ; RNA polymerase ; RNA, Circular - genetics ; Senescence ; Signal transduction ; Therapeutic applications ; Therapeutic targets ; Toxic diseases ; Toxicity
Is Part Of: Cardiovascular drugs and therapy, 2023-02, Vol.37 (1), p.181-198
Description: Circular RNA (circRNA) has a closed-loop structure, and its 3’ and 5’ ends are directly covalently connected by reverse splicing, which is more stable than linear RNA. CircRNAs usually possess microRNA (miRNA) binding sites, which can bind miRNAs and inhibit miRNA function. Many studies have shown that circRNAs are involved in the processes of cell senescence, proliferation and apoptosis and a series of signalling pathways, playing an important role in the prevention and treatment of diseases. CircRNAs are potential biological diagnostic markers and therapeutic targets for cardiovascular diseases (CVDs). To identify biomarkers and potential effective therapeutic targets without toxicity for heart disease, we summarize the biogenesis, biology, characterization and functions of circRNAs in CVDs, hoping that this information will shed new light on the prevention and treatment of CVDs.
Publisher: New York: Springer US
Language: English
Identifier: ISSN: 0920-3206
EISSN: 1573-7241
DOI: 10.1007/s10557-021-07228-5
PMID: 34269929
Source: MEDLINE
ProQuest Central

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The Function and Therapeutic Potential of Circular RNA in Cardiovascular Diseases

Springer Science+Business Media, LLC, part of Springer Nature 2021 ;2021. Springer Science+Business Media, LLC, part of Springer Nature. ;Springer Science+Business Media, LLC, part of Springer Nature 2021. ;ISSN: 0920-3206 ;EISSN: 1573-7241 ;DOI: 10.1007/s10557-021-07228-5 ;PMID: 34269929

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