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The GenomeAsia 100K Project enables genetic discoveries across Asia

Nature (London), 2019-12, Vol.576 (7785), p.106-111 [Tạp chí có phản biện]

COPYRIGHT 2019 Nature Publishing Group ;COPYRIGHT 2019 Nature Publishing Group ;The Author(s) 2019 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/s41586-019-1793-z ;PMID: 31802016

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Nhan đề:
The GenomeAsia 100K Project enables genetic discoveries across Asia
Tác giả: Wall, Jeffrey D ; Stawiski, Eric W ; Ratan, Aakrosh ; Kim, Hie Lim ; Kim, Changhoon ; Gupta, Ravi ; Suryamohan, Kushal
Chủ đề: Alleles ; Asians - genetics ; Datasets as Topic ; DNA sequencing ; Genetic research ; Genetic variation ; Genome, Human ; Genome-Wide Association Study ; Genotype ; Human genome ; Humans ; Identification and classification ; Methods ; Nucleotide sequencing
Là 1 phần của: Nature (London), 2019-12, Vol.576 (7785), p.106-111
Mô tả: The underrepresentation of non-Europeans in human genetic studies so far has limited the diversity of individuals in genomic datasets and led to reduced medical relevance for a large proportion of the world's population. Population-specific reference genome datasets as well as genome-wide association studies in diverse populations are needed to address this issue. Here we describe the pilot phase of the GenomeAsia 100K Project. This includes a whole-genome sequencing reference dataset from 1,739 individuals of 219 population groups and 64 countries across Asia. We catalogue genetic variation, population structure, disease associations and founder effects. We also explore the use of this dataset in imputation, to facilitate genetic studies in populations across Asia and worldwide.
Nơi xuất bản: England: Nature Publishing Group
Ngôn ngữ: English
Số nhận dạng: ISSN: 0028-0836
EISSN: 1476-4687
DOI: 10.1038/s41586-019-1793-z
PMID: 31802016
Nguồn: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
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The GenomeAsia 100K Project enables genetic discoveries across Asia

COPYRIGHT 2019 Nature Publishing Group ;COPYRIGHT 2019 Nature Publishing Group ;The Author(s) 2019 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/s41586-019-1793-z ;PMID: 31802016

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