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Bioprosthetic Pulmonary Valve Dysfunction in Congenital Heart Disease

The Annals of thoracic surgery, 2023-03, Vol.115 (3), p.641-648 [Peer Reviewed Journal]

2023 The Society of Thoracic Surgeons ;Copyright © 2023 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. ;ISSN: 0003-4975 ;EISSN: 1552-6259 ;DOI: 10.1016/j.athoracsur.2021.12.025 ;PMID: 35031286

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  • Title:
    Bioprosthetic Pulmonary Valve Dysfunction in Congenital Heart Disease
  • Author: Patel, Parth M. ; Zapata, David ; Qu, William ; Callahan, Mia ; Rao, Nikita ; Kelleman, Michael ; Kanter, Kirk R. ; Chai, Paul J. ; Shaw, Fawwaz R. ; Shashidharan, Subhadra ; Rosenblum, Joshua M.
  • Subjects: Animals ; Aortic Valve - surgery ; Bioprosthesis - adverse effects ; Cattle ; Heart Defects, Congenital - etiology ; Heart Defects, Congenital - surgery ; Heart Valve Prosthesis - adverse effects ; Heart Valve Prosthesis Implantation - adverse effects ; Prosthesis Design ; Pulmonary Valve - surgery ; Swine
  • Is Part Of: The Annals of thoracic surgery, 2023-03, Vol.115 (3), p.641-648
  • Description: We aim to identify the incidence and timing of dysfunction and failure of stented bioprosthetic valves in the pulmonary position in congenital heart disease patients. A total of 482 congenital heart disease patients underwent 484 stented bioprosthetic pulmonary valve implantations between 2008 and 2018. There were 164 porcine valves (Porcine) and 320 bovine pericardial valves (Pericardial) implanted. Primary endpoints were survival, valve dysfunction, and valve failure. Pericardial valves were implanted in older patients (22.0, interquartile range [IQR] 14-33 vs 16.0, IQR 11-23 years, P < 0.001). Five-year survival (96.7% vs 97.9%) for the Pericardial and Porcine groups, respectively, were similar, P > 0.05. Forty-six (34%) Porcine and 75 (27%) Pericardial group patients met criteria for valve dysfunction at a median echocardiographic follow-up time of 7.43 years (IQR 4.1-9.5 years) and 3.26 years (IQR 1.7-4.7 years), respectively. More Pericardial group patients suffered from at least mild late PR while late median peak gradient was higher in the Porcine group, P < .001 for both. Risk factors for valve dysfunction included decreasing patient age for the entire cohort (hazard ratio [HR] 1.02, 95% confidence interval [CI] 1.00-1.04, P = .015) and lack of anticoagulation at discharge for the Porcine group (HR 3.06, 95% CI 1.03-9.10, P = .044) but not the Pericardial group. Five-year cumulative incidence of dysfunction was 39% for the Pericardial group and 17% for the Porcine group. Porcine stented and bovine pericardial stented valves can be implanted in the pulmonary position in all age groups safely. However, despite similar rates of valve failure, bovine pericardial stented valves have a higher incidence of valve dysfunction at mid-term follow-up.
  • Publisher: Netherlands: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 0003-4975
    EISSN: 1552-6259
    DOI: 10.1016/j.athoracsur.2021.12.025
    PMID: 35031286
  • Source: MEDLINE
    Alma/SFX Local Collection
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