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The Role of Bamboo Shoot Gigantochloa Apus Extract in Decreasing the IL-17/IL-10 Ratio Level in the Atherosclerosis Process
Open access Macedonian journal of medical sciences, 2021-10, Vol.9 (A), p.817-821
ISSN: 1857-9655 ;EISSN: 1857-9655 ;DOI: 10.3889/oamjms.2021.6675
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Title:
The Role of Bamboo Shoot Gigantochloa Apus Extract in Decreasing the IL-17/IL-10 Ratio Level in the Atherosclerosis Process
Author:
Soesanto, Edy
;
Pranata, Satriya
;
Rejeki, Sri
;
Irham, Lalu Muhammad
Is Part Of:
Open access Macedonian journal of medical sciences, 2021-10, Vol.9 (A), p.817-821
Description:
BACKGROUND: Atherosclerosis begins with injury to the endothelial, progressive, and increases by 3% per year since the age of a person passes 20 years. The ratio of the number of pro and anti-inflammatory cytokines can describe the development of the process of atherosclerosis so that the higher the ratio will increase the chance of atherosclerosis. AIM: The purpose of this study was to examine the effect of Bamboo shoot Gigantochloa apus (BSGA) extract on decreasing interleukin-17 (IL-17)/IL-10 level ratios in New Zealand White rabbits given an atherogenic diet. METHODS: This study uses BSGA extract freeze-dried aged 1–2 weeks and New Zealand White rabbits. Atherogenic feed uses 0.5% egg yolk and 5% pork oil which is added to the standard feed. Randomized pre- and post-test with control group design by dividing into four groups were used in this study. RESULTS: The mean ratio of IL-17 levels with IL-10 between before and after (p < 0.005) in all groups showed a significant difference. There was a trend of increasing the ratio between IL-17 levels and IL-10 in all groups and the highest increase occurred in the control group which was 420%. CONCLUSION: The higher the dose of BSGA extract administration could reduce the ratio between IL-17 levels and IL-10 and there is a correlation with a negative linear pattern between IL-10 and IL-17 with p = 0.034 which means that higher levels of IL-10 will reduce IL-17 levels.
Language:
English
Identifier:
ISSN: 1857-9655
EISSN: 1857-9655
DOI: 10.3889/oamjms.2021.6675
Source:
ROAD: Directory of Open Access Scholarly Resources
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