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Denser Growing Fiber Connections Induce 3-hinge Gyral Folding

Cerebral cortex (New York, N.Y. 1991), 2018-03, Vol.28 (3), p.1064-1075 [Peer Reviewed Journal]

The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2017 ;The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. ;ISSN: 1047-3211 ;EISSN: 1460-2199 ;DOI: 10.1093/cercor/bhx227 ;PMID: 28968837

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  • Title:
    Denser Growing Fiber Connections Induce 3-hinge Gyral Folding
  • Author: Ge, Fangfei ; Li, Xiao ; Razavi, Mir Jalil ; Chen, Hanbo ; Zhang, Tuo ; Zhang, Shu ; Guo, Lei ; Hu, Xiaoping ; Wang, Xianqiao ; Liu, Tianming
  • Subjects: Original
  • Is Part Of: Cerebral cortex (New York, N.Y. 1991), 2018-03, Vol.28 (3), p.1064-1075
  • Description: Abstract Recent studies have shown that quantitative description of gyral shape patterns offers a novel window to examine the relationship between brain structure and function. Along this research line, this paper examines a unique and interesting type of cortical gyral region where 3 different gyral crests meet, termed 3-hinge gyral region. We extracted 3-hinge gyral regions in macaque/chimpanzee/human brains, quantified and compared the relevant DTI-derived fiber densities in 3-hinge and 2-hinge gyral regions. Our observations consistently showed that DTI-derived fiber densities in 3-hinge regions are much higher than those in 2-hinge regions. Therefore, we hypothesize that besides the cortical expansion, denser fiber connections can induce the formation of 3-hinge gyri. To examine the biomechanical basis of this hypothesis, we constructed a series of 3-dimensional finite element soft tissue models based on continuum growth theory to investigate fundamental biomechanical mechanisms of consistent 3-hinge gyri formation. Our computational simulation results consistently showed that during gyrification gyral regions with higher concentrations of growing axonal fibers tend to form 3-hinge gyri. Our integrative approach combining neuroimaging data analysis and computational modeling appears effective in probing a plausible theory of 3-hinge gyri formation and providing new insights into structural and functional cortical architectures and their relationship.
  • Publisher: United States: Oxford University Press
  • Language: English
  • Identifier: ISSN: 1047-3211
    EISSN: 1460-2199
    DOI: 10.1093/cercor/bhx227
    PMID: 28968837
  • Source: Alma/SFX Local Collection
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