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Frameshift mutation, microsatellites and mismatch repair

Mutation research, 1999-11, Vol.437 (3), p.195-203 [Peer Reviewed Journal]

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Title:
Frameshift mutation, microsatellites and mismatch repair
Author: Strauss, Bernard S.
Subjects: Base Pair Mismatch ; Biological and medical sciences ; DNA polymerase ; DNA Repair - genetics ; DNA Replication ; Escherichia coli - genetics ; Eukaryotic Cells ; Frameshift mutation ; Frameshift Mutation - genetics ; Fundamental and applied biological sciences. Psychology ; Genetic stability ; Homopolymer runs ; Microsatellite Repeats - genetics ; Mismatch repair ; Molecular and cellular biology ; Molecular genetics ; Mutagenesis. Repair ; Mutagens ; Prokaryotic Cells
Is Part Of: Mutation research, 1999-11, Vol.437 (3), p.195-203
Description: The structure of eukaryotic DNA, with its repeated sequences, makes base addition and loss a major obstacle to the maintenance of genetic stability. As compared to the bacteria, much of the mismatch repair capacity of the eukaryotic cell must be devoted to the surveillance of frameshift changes. Any alteration in the activity of proteins which recognize frameshifts or which hold the DNA in place during replication is likely to result in genomic instability.
Publisher: Lausanne: Elsevier B.V
Language: English
Identifier: ISSN: 1383-5742
ISSN: 0027-5107
EISSN: 1388-2139
EISSN: 1873-135X
DOI: 10.1016/S1383-5742(99)00066-6
PMID: 10592327
Source: MEDLINE
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