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Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence

Journal of clinical medicine, 2020-05, Vol.9 (5), p.1417 [Peer Reviewed Journal]

2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2020 by the authors. 2020 ;ISSN: 2077-0383 ;EISSN: 2077-0383 ;DOI: 10.3390/jcm9051417 ;PMID: 32403217

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Title:
Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence
Author: Sardu, Celestino ; Gambardella, Jessica ; Morelli, Marco Bruno ; Wang, Xujun ; Marfella, Raffaele ; Santulli, Gaetano
Subjects: ACE2, acute kidney injury ; Anticoagulants ; Avian flu ; Blood pressure ; catepsin ; coronavirus ; Coronaviruses ; COVID ; COVID-19 ; cytokine storm ; Diabetes ; Disease ; Endothelium ; Gene expression ; Glycoproteins ; Hospitals ; Hypertension ; Infections ; Morbidity ; Mortality ; Pathogenesis ; Proteins ; Review ; Severe acute respiratory syndrome coronavirus 2 ; Thrombosis ; Ventilators
Is Part Of: Journal of clinical medicine, 2020-05, Vol.9 (5), p.1417
Description: The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic disorders, and diabetes mellitus) indicate that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report a systematic and comprehensive evaluation of both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ in COVID-19, providing a mechanistic rationale behind its systemic manifestations.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 2077-0383
EISSN: 2077-0383
DOI: 10.3390/jcm9051417
PMID: 32403217
Source: Open Access: DOAJ Directory of Open Access Journals
Open Access: PubMed Central
AUTh Library subscriptions: ProQuest Central
Coronavirus Research Database
ROAD: Directory of Open Access Scholarly Resources

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Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence

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