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Antimicrobial proteins
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Title:
Antimicrobial proteins
Author:
Griessl, Martin
;
Biebl, Manfred
Subjects:
AGRICULTURE
;
ANIMAL HUSBANDRY
;
BEER
;
BIOCHEMISTRY
;
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
;
CHEMISTRY
;
COMPOSITIONS THEREOF
;
CULTURE MEDIA
;
ENZYMOLOGY
;
FISHING
;
FORESTRY
;
HUMAN NECESSITIES
;
HUNTING
;
HYGIENE
;
MEDICAL OR VETERINARY SCIENCE
;
METALLURGY
;
MICROBIOLOGY
;
MICROORGANISMS OR ENZYMES
;
MUTATION OR GENETIC ENGINEERING
;
ORGANIC CHEMISTRY
;
PEPTIDES
;
PEST REPELLANTS OR ATTRACTANTS
;
PLANT GROWTH REGULATORS
;
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
;
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
;
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
;
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
;
SPIRITS
;
TRAPPING
;
VINEGAR
;
WINE
Description:
The present invention relates to a polypeptide comprising a Gram negative endolysin and a peptide selected from the group consisting of an antimicrobial peptide, an amphipathic peptide, a cationic peptide, a sushi peptide or a defensin, wherein the endolysin in turn is selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9 and sequences having at least 80% sequence identity with SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8 and/or SEQ ID NO:9. The present invention relates also to corresponding nucleic acids, vectors, bacteriophages, host cells, compositions and kits. The present inventions also relates to the use of said polypeptides, nucleic acids, vectors, bacteriophages, host cells, compositions and kits in methods for treatment of the human or animal body by surgery or therapy or in diagnostic methods practiced on the human or animal body. The polypeptides, nucleic acids, vectors, bacteriophages, host cells, compositions and kits according to the invention may also be used as an antimicrobial in, e.g., food or feed, in cosmetics, or as disinfecting agent.
Creation Date:
2024
Language:
English
Source:
esp@cenet
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