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Artificial light at night suppresses the expression of sarco/endoplasmic reticulum Ca2+‐ATPase in the left ventricle of the heart in normotensive and hypertensive rats

Experimental physiology, 2021-08, Vol.106 (8), p.1762-1771 [Peer Reviewed Journal]

2021 The Authors. Experimental Physiology © 2021 The Physiological Society ;2021 The Physiological Society ;ISSN: 0958-0670 ;EISSN: 1469-445X ;DOI: 10.1113/EP089594

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  • Title:
    Artificial light at night suppresses the expression of sarco/endoplasmic reticulum Ca2+‐ATPase in the left ventricle of the heart in normotensive and hypertensive rats
  • Author: Sutovska, Hana ; Miklovic, Matus ; Molcan, Lubos
  • Subjects: Adenosine triphosphatase ; Angiotensin ; Angiotensin II ; angiotensin II receptor type 1 ; artificial light at night ; Autonomic nervous system ; Ca2+-transporting ATPase ; Calcium (reticular) ; Circadian rhythms ; Endoplasmic reticulum ; Endothelins ; Heart ; Heart rate ; Hydroxylase ; Hypertension ; Light sources ; Muscle contraction ; rats ; Regulatory proteins ; Rodents ; sarco/endoplasmic reticulum Ca2+‐ATPase ; the left ventricle of the heart ; Tyrosine 3-monooxygenase ; Ventricle
  • Is Part Of: Experimental physiology, 2021-08, Vol.106 (8), p.1762-1771
  • Description: New Findings What is the central question of this study? Artificial light at night decreases blood pressure and heart rate in rats. Are these changes in heart rate accompanied by changes in protein expression in the heart's left ventricle? What is the main finding and its importance? Five weeks of artificial light at night affected protein expression in the heart's left ventricle in normotensive and hypertensive rats. Artificial light at night decreased expression of the sarco/endoplasmic reticulum Ca2+‐ATPase, angiotensin II receptor type 1 and endothelin‐1. Artificial light at night (ALAN) affects the circadian rhythm of the heart rate in normotensive Wistar rats (WT) and spontaneously hypertensive rats (SHR) through the autonomic nervous system, which regulates the heart's activity through calcium handling, an important regulator in heart contractility. We analysed the expression of the sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA2) and other selected regulatory proteins involved in the regulation of heart contractility, angiotensin II receptor type 1 (AT1R), endothelin‐1 (ET‐1) and tyrosine hydroxylase (TH), in the left ventricle of the heart in WT and SHR after 2 and 5 weeks of ALAN with intensity 1–2 lx. Expression of SERCA2 was decreased in WT (control: 0.53 ± 0.07; ALAN: 0.46 ± 0.10) and SHR (control: 0.72 ± 0.18; ALAN: 0.56 ± 0.21) after 5 weeks of ALAN (P = 0.067). Expression of AT1R was significantly decreased in WT (control: 0.51 ± 0.27; ALAN: 0.34 ± 0.20) and SHR (control: 0.38 ± 0.07; ALAN: 0.23 ± 0.09) after 2 weeks of ALAN (P = 0.028) and in SHR after 5 weeks of ALAN. Expression of ET‐1 was decreased in WT (control: 0.51 ± 0.27; ALAN: 0.28 ± 0.12) and SHR (control: 0.54 ± 0.10; ALAN: 0.35 ± 0.23) after 5 weeks of ALAN (P = 0.015). ALAN did not affect the expression of TH in WT or SHR. In conclusion, ALAN suppressed the expression of SERCA2, AT1R and ET‐1, which are important for the regulation of heart contractility, in a strain‐dependent pattern in both WT and SHR.
  • Publisher: Oxford: John Wiley & Sons, Inc
  • Language: English
  • Identifier: ISSN: 0958-0670
    EISSN: 1469-445X
    DOI: 10.1113/EP089594
  • Source: Journals@Ovid Open Access Journal Collection Rolling
    Geneva Foundation Free Medical Journals at publisher websites
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