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Effect of Helicobacter pylori infection on the risk of acute coronary syndrome: A systematic review and meta-analysis

Medicine (Baltimore), 2019-12, Vol.98 (50), p.e18348-e18348 [Peer Reviewed Journal]

Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. 2019 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/md.0000000000018348 ;PMID: 31852134

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  • Title:
    Effect of Helicobacter pylori infection on the risk of acute coronary syndrome: A systematic review and meta-analysis
  • Author: Fang, Yizhen ; Fan, Chunming ; Xie, Huabin
  • Subjects: Acute Coronary Syndrome - microbiology ; Developing Countries ; Helicobacter Infections - complications ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Humans ; Odds Ratio ; Risk Factors ; Systematic Review and Meta-Analysis
  • Is Part Of: Medicine (Baltimore), 2019-12, Vol.98 (50), p.e18348-e18348
  • Description: Numerous studies have illustrated the association between Helicobacter pylori (H pylori) infection and acute coronary syndrome (ACS). However, the results are contradictory. Therefore, we conducted the meta-analysis to identify the association between H pylori and ACS. We performed a systematic search through electronic databases (Excerpta Medica Database, PubMed, Cochrane Library, and Web of Science). Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with a random effect model. We also carried out the sensitivity analysis and publication bias. Forty-four eligible studies involving 7522 cases and 8311 controls were included. The pooled result showed that H pylori infection was associated with an increase risk of ACS (OR = 2.03, 95% CI 1.66-2.47). In addition, similar results were obtained in subgroups of study quality, area, human development index, and H pylori detection method. The OR for developing countries was significantly higher than developed countries (OR = 2.58 vs OR = 1.69). Moreover, H pylori with cytotoxin-associated antigen A was also significantly associated with an increase risk of ACS (OR = 2.39, 95% CI 1.21-4.74). The meta-analysis suggested that H pylori infection was associated with an increased risk of ACS, especially in developing countries. H pylori is easily screened and can be treated with a wide range of drugs. Thus, more high-quality and well-designed studies are needed to confirm whether the treatment of H pylori is an effective way to reduce ACS risk.
  • Publisher: United States: Wolters Kluwer Health
  • Language: English
  • Identifier: ISSN: 0025-7974
    EISSN: 1536-5964
    DOI: 10.1097/md.0000000000018348
    PMID: 31852134
  • Source: IngentaConnect
    PubMed (Medline)
    Journals@Ovid Open Access Journal Collection Rolling
    Wolters Kluwer Open Health
    MEDLINE
    DOAJ Directory of Open Access Journals
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