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Production of Androgens by Microbial Transformation of Progesterone in Vitro: A Model for Androgen Production in Rivers Receiving Paper Mill Effluent

Environmental health perspectives, 2004-11, Vol.112 (15), p.1508-1511 [Peer Reviewed Journal]

COPYRIGHT 2004 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences Nov 2004 ;ISSN: 0091-6765 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.7161 ;PMID: 15531435

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  • Title:
    Production of Androgens by Microbial Transformation of Progesterone in Vitro: A Model for Androgen Production in Rivers Receiving Paper Mill Effluent
  • Author: Jenkins, Ronald L. ; Wilson, Elizabeth M. ; Angus, Robert A. ; Howell, W. Mike ; Kirk, Marion ; Moore, Ray ; Nance, Marione ; Brown, Amber
  • Subjects: 17 alpha -Hydroxyprogesterone ; Androgen receptors ; Androgens ; Estrogens ; Mycobacterium smegmatis ; Paper mills ; Phytosterols ; Pulp and paper mill effluents ; River water ; Sediments ; Steroids ; Sterols
  • Is Part Of: Environmental health perspectives, 2004-11, Vol.112 (15), p.1508-1511
  • Description: We have previously documented the presence of progesterone and androstenedione in the water column and bottom sediments of the Fenholloway River, Taylor County, Florida. This river receives paper mill effluent and contains masculinized female mosquitofish. We hypothesized that plant sterols (e.g., β-sitosterol) derived from the pulping of pine trees are transformed by bacteria into progesterone and subsequently into 17α-hydroxyprogesterone, androstenedione, and other androgens. In this study, we demonstrate that these same androgens can be produced in vitro from the bacterium Mycobacterium smegmatis. In a second part to this study, we reextracted and reanalyzed the sediment from the Fenholloway River and verified the presence of androstadienedione, a Δ1 steroid with androgen activity.
  • Publisher: Research Triangle Park: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
  • Language: English
  • Identifier: ISSN: 0091-6765
    EISSN: 1552-9924
    DOI: 10.1289/ehp.7161
    PMID: 15531435
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Open Access: PubMed Central
    US Government Documents
    AUTh Library subscriptions: ProQuest Central
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