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Clinical implications of intratumor heterogeneity: challenges and opportunities

Journal of molecular medicine (Berlin, Germany), 2020-02, Vol.98 (2), p.161-177 [Peer Reviewed Journal]

The Author(s) 2020 ;COPYRIGHT 2020 Springer ;Journal of Molecular Medicine is a copyright of Springer, (2020). All Rights Reserved. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0946-2716 ;EISSN: 1432-1440 ;DOI: 10.1007/s00109-020-01874-2 ;PMID: 31970428

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Title:
Clinical implications of intratumor heterogeneity: challenges and opportunities
Author: Ramón y Cajal, Santiago ; Sesé, Marta ; Capdevila, Claudia ; Aasen, Trond ; De Mattos-Arruda, Leticia ; Diaz-Cano, Salvador J. ; Hernández-Losa, Javier ; Castellví, Josep
Subjects: Adaptability ; Animals ; Artificial intelligence ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cell survival ; Chemotherapy ; Epigenesis, Genetic ; Epigenetic inheritance ; Epigenetics ; Genetic Heterogeneity ; Histochemistry ; Human Genetics ; Humans ; Hypoxia ; Internal Medicine ; Medical research ; Medicine, Experimental ; Metastases ; Metastasis ; Molecular Medicine ; Natural selection ; Neoplasms - genetics ; Neoplasms - therapy ; Phenotype ; Research institutes ; Review ; Tumor Microenvironment ; Tumors
Is Part Of: Journal of molecular medicine (Berlin, Germany), 2020-02, Vol.98 (2), p.161-177
Description: In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through complex genetic, epigenetic, and protein modifications that drive phenotypic selection in response to environmental pressures. Functionally, heterogeneity provides tumors with significant adaptability. This ranges from mutual beneficial cooperation between cells, which nurture features such as growth and metastasis, to the narrow escape and survival of clonal cell populations that have adapted to thrive under specific conditions such as hypoxia or chemotherapy. These dynamic intercellular interplays are guided by a Darwinian selection landscape between clonal tumor cell populations and the tumor microenvironment. Understanding the involved drivers and functional consequences of such tumor heterogeneity is challenging but also promises to provide novel insight needed to confront the problem of therapeutic resistance in tumors.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 0946-2716
EISSN: 1432-1440
DOI: 10.1007/s00109-020-01874-2
PMID: 31970428
Source: SpringerOpen
MEDLINE
ProQuest Central

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Clinical implications of intratumor heterogeneity: challenges and opportunities

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