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Family history of cardiovascular disease and non-HDL cholesterol in prepubescent non-obese children

Revista da Associacao Medica Brasileira (1992), 2016-07, Vol.62 (4), p.347-352 [Peer Reviewed Journal]

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. ;ISSN: 0104-4230 ;ISSN: 1806-9282 ;EISSN: 1806-9282 ;EISSN: 0104-4230 ;DOI: 10.1590/1806-9282.62.04.347 ;PMID: 27437681

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Title:
Family history of cardiovascular disease and non-HDL cholesterol in prepubescent non-obese children
Author: Strufaldi, Maria Wany Louzada ; Souza, Fabíola Isabel Suano de ; Puccini, Rosana Fiorini ; Franco, Maria do Carmo Pinho
Subjects: Cardiovascular Diseases - blood ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - prevention & control ; Child ; Cholesterol, HDL - blood ; Cholesterol, HDL - genetics ; Cross-Sectional Studies ; Dyslipidemias - blood ; Dyslipidemias - genetics ; Dyslipidemias - prevention & control ; Female ; Humans ; Male ; MEDICINE, GENERAL & INTERNAL ; Risk Factors ; Waist Circumference
Is Part Of: Revista da Associacao Medica Brasileira (1992), 2016-07, Vol.62 (4), p.347-352
Description: To describe the values of non-HDL cholesterol (NHDL-c) and the frequency of a family history of early cardiovascular disease (family HCVD) in healthy prepubescent children. Analyze the association between NHDL-c and family HCVD, and possible associations with other risk factors for cardiovascular disease (CVD). Cross-sectional study including 269 prepubescent (aged 6-10 years) schoolchildren with a normal body mass index (+1SD-2SD). Family HCVD; weight and height, waist circumference and systemic blood pressure; lipid profile (total cholesterol TC, HDL-c, triglycerides and LDL-c), NHDL-c calculation (CT-HDL-c, cut-off = 145 mg/dL) and insulin resistance (HOMA-IR). High levels were found for NHDL-c in 10 (3.7%) of these schoolchildren, and family early HCVD was found in 46 (17.1%) of them. There was a weak association between family HCVD and NHDL-c (Cramer's-V-test = 0.120; p=0.050). Among the children with NHDL-c≥145 mg/dL, 4 (40%) have family HCVD. The presence of family HCVD was not associated with the variables being studied. The variables independently associated with NHDL-c ≥ 145 mg/dL were: HOMA-IR (OR=1.7; 95CI 1.1-2.6) and diastolic blood pressure (OR=1.1; 95CI 1.02-1.2). NHDL-c values were associated with blood pressure and insulin resistance. Family HCVD was not associated with other classic risk factors for CVD, even though the frequency found was five times higher than that of high NHDL-c.
Publisher: Brazil: Associação Médica Brasileira
Language: English;Portuguese
Identifier: ISSN: 0104-4230
ISSN: 1806-9282
EISSN: 1806-9282
EISSN: 0104-4230
DOI: 10.1590/1806-9282.62.04.347
PMID: 27437681
Source: SciELO

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Family history of cardiovascular disease and non-HDL cholesterol in prepubescent non-obese children

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. ;ISSN: 0104-4230 ;ISSN: 1806-9282 ;EISSN: 1806-9282 ;EISSN: 0104-4230 ;DOI: 10.1590/1806-9282.62.04.347 ;PMID: 27437681

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