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Autophagy in Cardiovascular Aging

Circulation research, 2018-09, Vol.123 (7), p.803-824 [Peer Reviewed Journal]

2018 American Heart Association, Inc. ;ISSN: 0009-7330 ;ISSN: 1524-4571 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.118.312208 ;PMID: 30355077

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Title:
Autophagy in Cardiovascular Aging
Author: Abdellatif, Mahmoud ; Sedej, Simon ; Carmona-Gutierrez, Didac ; Madeo, Frank ; Kroemer, Guido
Subjects: Age Factors ; Aging - metabolism ; Aging - pathology ; Animals ; Autophagy - drug effects ; Caloric Restriction ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - pathology ; Cardiovascular Diseases - physiopathology ; Cardiovascular Diseases - prevention & control ; Cardiovascular System - drug effects ; Cardiovascular System - metabolism ; Cardiovascular System - pathology ; Cardiovascular System - physiopathology ; Health Status ; Humans ; Longevity ; Medicin och hälsovetenskap ; Metformin - therapeutic use ; Protective Factors ; Risk Factors ; Sirolimus - therapeutic use ; Spermidine - therapeutic use
Is Part Of: Circulation research, 2018-09, Vol.123 (7), p.803-824
Description: Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life- and health-span extension. We present genetic models, pharmacological interventions, and dietary strategies that block, reduce, or enhance autophagy upon age-related cardiovascular deterioration. Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are among the most promising cardioprotective interventions during aging. We conclude that autophagy is a fundamental process to ensure cardiac and vascular health during aging and outline its putative therapeutic importance.
Publisher: United States: American Heart Association, Inc
Language: English
Identifier: ISSN: 0009-7330
ISSN: 1524-4571
EISSN: 1524-4571
DOI: 10.1161/CIRCRESAHA.118.312208
PMID: 30355077
Source: Geneva Foundation Free Medical Journals at publisher websites
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Autophagy in Cardiovascular Aging

2018 American Heart Association, Inc. ;ISSN: 0009-7330 ;ISSN: 1524-4571 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.118.312208 ;PMID: 30355077

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