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Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants

BMJ (Online), 2018-05, Vol.361, p.k1651-k1651 [Peer Reviewed Journal]

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. ;Copyright: 2018 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to 2018 BMJ ;ISSN: 0959-8138 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.k1651 ;PMID: 29739772

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Title:
Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants
Author: Celis-Morales, Carlos A ; Welsh, Paul ; Lyall, Donald M ; Steell, Lewis ; Petermann, Fanny ; Anderson, Jana ; Iliodromiti, Stamatina ; Sillars, Anne ; Graham, Nicholas ; Mackay, Daniel F ; Pell, Jill P ; Gill, Jason M R ; Sattar, Naveed ; Gray, Stuart R
Subjects: Adult ; Age ; Aged ; Aging ; Blood pressure ; Body composition ; Body mass index ; Breast cancer ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - physiopathology ; Cause of Death ; Chronic illnesses ; Chronic obstructive pulmonary disease ; Codes ; Colon cancer ; Colorectal cancer ; Colorectal carcinoma ; Diabetes ; Diabetes mellitus ; Epidemiology ; Female ; Hand Strength - physiology ; Health risk assessment ; Hospitals ; Humans ; Incidence ; Lung cancer ; Lung diseases ; Male ; Metabolism ; Middle Aged ; Mortality ; Musculoskeletal system ; Obstructive lung disease ; Older people ; Population studies ; Prospective Studies ; Prostate ; Prostate cancer ; Pulmonary Disease, Chronic Obstructive - mortality ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Respiratory diseases ; Respiratory Tract Diseases - mortality ; Respiratory Tract Diseases - physiopathology ; Risk Factors ; Sarcopenia ; Smoking ; Socioeconomic factors ; United Kingdom - epidemiology ; Womens health
Is Part Of: BMJ (Online), 2018-05, Vol.361, p.k1651-k1651
Description: AbstractObjectiveTo investigate the association of grip strength with disease specific incidence and mortality and whether grip strength enhances the prediction ability of an established office based risk score.DesignProspective population based study.SettingUK Biobank.Participants502 293 participants (54% women) aged 40-69 years.Main outcome measuresAll cause mortality as well as incidence of and mortality from cardiovascular disease, respiratory disease, chronic obstructive pulmonary disease, and cancer (all cancer, colorectal, lung, breast, and prostate).ResultsOf the participants included in analyses, 13 322 (2.7%) died over a mean of 7.1 (range 5.3-9.9) years’ follow-up. In women and men, respectively, hazard ratios per 5 kg lower grip strength were higher (all at P<0.05) for all cause mortality (1.20, 95% confidence interval 1.17 to 1.23, and 1.16, 1.15 to 1.17) and cause specific mortality from cardiovascular disease (1.19, 1.13 to 1.25, and 1.22, 1.18 to 1.26), all respiratory disease (1.31, 1.22 to 1.40, and 1.24, 1.20 to 1.28), chronic obstructive pulmonary disease (1.24, 1.05 to 1.47, and 1.19, 1.09 to 1.30), all cancer (1.17, 1.13 to 1.21, 1.10, 1.07 to 1.13), colorectal cancer (1.17, 1.04 to 1.32, and 1.18, 1.09 to 1.27), lung cancer (1.17, 1.07 to 1.27, and 1.08, 1.03 to 1.13), and breast cancer (1.24, 1.10 to 1.39) but not prostate cancer (1.05, 0.96 to 1.15). Several of these relations had higher hazard ratios in the younger age group. Muscle weakness (defined as grip strength <26 kg for men and <16 kg for women) was associated with a higher hazard for all health outcomes, except colon cancer in women and prostate cancer and lung cancer in both men and women. The addition of handgrip strength improved the prediction ability, based on C index change, of an office based risk score (age, sex, diabetes diagnosed, body mass index, systolic blood pressure, and smoking) for all cause (0.013) and cardiovascular mortality (0.012) and incidence of cardiovascular disease (0.009).ConclusionHigher grip strength was associated with a range of health outcomes and improved prediction of an office based risk score. Further work on the use of grip strength in risk scores or risk screening is needed to establish its potential clinical utility.
Publisher: England: BMJ Publishing Group LTD
Language: English
Identifier: ISSN: 0959-8138
EISSN: 1756-1833
DOI: 10.1136/bmj.k1651
PMID: 29739772
Source: BMJ Open Access Journals
MEDLINE
ProQuest Central

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Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants

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