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Prenatal Bisphenol A Exposure and Early Childhood Behavior

Environmental health perspectives, 2009-12, Vol.117 (12), p.1945-1952 [Peer Reviewed Journal]

COPYRIGHT 2009 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences Dec 2009 ;2009 ;ISSN: 0091-6765 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.0900979 ;PMID: 20049216

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  • Title:
    Prenatal Bisphenol A Exposure and Early Childhood Behavior
  • Author: Braun, Joe M. ; Yolton, Kimberly ; Dietrich, Kim N. ; Hornung, Richard ; Ye, Xiaoyun ; Calafat, Antonia M. ; Lanphear, Bruce P.
  • Subjects: Adult ; Behavior ; Benzhydryl Compounds ; Bisphenol-A ; Bisphenols ; Chemical hazards ; Child Behavior - drug effects ; Child, Preschool ; Childhood ; Childhood mental disorders ; Children ; Children's Health ; Environmental health ; Epidemiology ; Female ; Fetus - drug effects ; Health aspects ; High performance liquid chromatography ; Humans ; Male ; Phenols - toxicity ; Phenols - urine ; Pregnancy ; Psychological aspects ; Reproduction ; Sex Characteristics ; Urine
  • Is Part Of: Environmental health perspectives, 2009-12, Vol.117 (12), p.1945-1952
  • Description: Background: Prenatal exposure to bisphenol A (BPA) increases offspring aggression and diminishes differences in sexually dimorphic behaviors in rodents. Objective: We examined the association between prenatal BPA exposure and behavior in 2-year-old children. Methods: We used data from 249 mothers and their children in Cincinnati, Ohio (USA). Maternal urine was collected around 16 and 26 weeks of gestation and at birth. BPA concentrations were quantified using high-performance liquid chromatography–isotope-dilution tandem mass spectrometry. Child behavior was assessed at 2 years of age using the second edition of the Behavioral Assessment System for Children (BASC-2). The association between prenatal BPA concentrations and BASC-2 scores was analyzed using linear regression. Results: Median BPA concentrations were 1.8 (16 weeks), 1.7 (26 weeks), and 1.3 (birth) ng/mL. Mean (± SD) BASC-2 externalizing and internalizing scores were 47.6 ± 7.8 and 44.8 ± 7.0, respectively. After adjustment for confounders,$log_{10}$-transformed mean prenatal BPA concentrations were associated with externalizing scores, but only among females [β = 6.0; 95% confidence interval (CI), 0.1-12.0]. Compared with 26-week and birth concentrations, BPA concentrations collected around 16 weeks were more strongly associated with externalizing scores among all children (β = 2.9; 95% CI, 0.2-5.7), and this association was stronger in females than in males. Among all children, measurements collected at ≤ 16 weeks showed a stronger association (β = 5.1; 95% CI, 1.5-8.6) with externalizing scores than did measurements taken at 17-21 weeks ( β = 0.6; 95% CI, -2.9 to 4.1). Conclusions: These results suggest that prenatal BPA exposure may be associated with externalizing behaviors in 2-year-old children, especially among female children.
  • Publisher: United States: National Institute of Environmental Health Sciences
  • Language: English
  • Identifier: ISSN: 0091-6765
    EISSN: 1552-9924
    DOI: 10.1289/ehp.0900979
    PMID: 20049216
  • Source: US Government Documents
    MEDLINE
    PubMed Central(OpenAccess)
    Directory of Open Access Journals(OpenAccess)
    ProQuest Central
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